Detailed view for EgrG_001009400

Basic information

TDR Targets ID: 592957
Echinococcus granulosus, Kv channel interacting protein 4
Source Database / ID:  GeneDB

pI: 6.9546 | Length (AA): 208 | MW (Da): 23596 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13499   EF-hand domain pair

Gene Ontology

Mouse over links to read term descriptions.
GO:0005509   calcium ion binding  

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
12 206 3dd4 (A) 33 227 40.00 0 1 1.3732 -0.16
22 206 2d8n (A) 5 190 25.00 0.00000018 1 1.33032 -1.14
22 202 5g08 (A) 4 183 25.00 0.000000033 1 1.32009 -1.13
31 208 1s1e (A) 39 216 38.00 0.00000000017 1 1.43367 -1.11
160 206 2ma2 (A) 424 466 49.00 0.19 0.14 0.440162 0.32

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131887)

Species Accession Gene Product
Arabidopsis thaliana AT5G10930   CBL-interacting protein kinase 5
Arabidopsis thaliana AT5G07070   CBL-interacting protein kinase 2
Arabidopsis thaliana AT5G58380   CBL-interacting serine/threonine-protein kinase 10
Arabidopsis thaliana AT5G25110   CBL-interacting serine/threonine-protein kinase 25
Babesia bovis BBOV_II000610   asparagine rich protein, putative
Echinococcus granulosus EgrG_001009400   Kv channel interacting protein 4
Echinococcus multilocularis EmuJ_001009400   Kv channel interacting protein 4
Neospora caninum NCLIV_044860   hypothetical protein
Oryza sativa 4332786   Os03g0339900
Oryza sativa 4338445   Os05g0332300
Oryza sativa 4344287   Os07g0678600
Plasmodium berghei PBANKA_0925200   calcium-dependent protein kinase 7
Plasmodium falciparum PF3D7_1123100   calcium-dependent protein kinase 7
Plasmodium knowlesi PKNH_0920900   calcium-dependent protein kinase 7, putative
Plasmodium vivax PVX_091770   calcium-dependent protein kinase 7, putative
Plasmodium yoelii PY00029   myosin light chain kinase
Toxoplasma gondii TGME49_228750   calcium dependent protein kinase CDPK7
Theileria parva TP04_0518   protein kinase, putative

Essentiality

EgrG_001009400 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_0925200 Plasmodium berghei Essential plasmo
TGME49_228750 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Bos taurus Calmodulin 149 aa 27.8% 151 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EgrG_001009400 (Echinococcus granulosus), Kv channel interacting protein 4
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