pI: 7.2335 |
Length (AA): 301 |
MW (Da): 33905 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
20 | 298 | 1ei9 (A) | 29 | 306 | 47.00 | 0 | 1 | 1.59441 | -1.16 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_129289)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G17483 | putative palmitoyl-(protein) hydrolase |
Arabidopsis thaliana | AT5G47350 | alpha/beta-Hydrolases superfamily protein |
Arabidopsis thaliana | AT3G60340 | palmitoyl protein thioesterase family protein |
Arabidopsis thaliana | AT4G17480 | palmitoyl protein thioesterase family protein |
Arabidopsis thaliana | AT5G47330 | palmitoyl protein thioesterase family protein |
Arabidopsis thaliana | AT5G47340 | palmitoyl protein thioesterase family protein |
Arabidopsis thaliana | AT4G17470 | putative palmitoyl-protein thioesterase |
Brugia malayi | Bm1_51565 | Palmitoyl-protein thioesterase 1 precursor |
Candida albicans | CaO19.540 | palmitoyl protein thioesterase similar to C. elegans ppt-1 (F44C4.5) |
Candida albicans | CaO19.8173 | palmitoyl protein thioesterase similar to C. elegans ppt-1 (F44C4.5) |
Caenorhabditis elegans | CELE_F44C4.5 | Protein PPT-1 |
Dictyostelium discoideum | DDB_G0285533 | palmitoyl-protein thioesterase 1 |
Drosophila melanogaster | Dmel_CG12108 | Palmitoyl-protein thioesterase 1 |
Echinococcus granulosus | EgrG_000468100 | palmitoyl protein thioesterase 1 |
Echinococcus multilocularis | EmuJ_000468100 | palmitoyl protein thioesterase 1 |
Homo sapiens | ENSG00000131238 | palmitoyl-protein thioesterase 1 |
Loa Loa (eye worm) | LOAG_00055 | palmitoyl-protein thioesterase 1 |
Mus musculus | ENSMUSG00000028657 | palmitoyl-protein thioesterase 1 |
Mus musculus | 102632555 | predicted gene 12873 |
Oryza sativa | 4331284 | Os03g0101100 |
Oryza sativa | 4349396 | Os10g0563000 |
Schistosoma japonicum | Sjp_0202470 | ko:K01074 palmitoyl-protein thioesterase [EC3.1.2.22], putative |
Schistosoma mansoni | Smp_142970 | palmitoyl-protein thioesterase |
Schmidtea mediterranea | mk4.002477.01 | Palmitoyl-protein thioesterase 1 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | palmitoyl-protein thioesterase 1 | Compounds | References |