Detailed view for EgrG_000821500

Basic information

TDR Targets ID: 593868
Echinococcus granulosus, immediate early response 3 interacting protein
Source Database / ID:  GeneDB

pI: 8.8012 | Length (AA): 126 | MW (Da): 14386 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF08571   Yos1-like

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
31 102 4q3l (A) 156 235 28.00 0.15 0.03 0.633429 1.02

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130002)

Species Accession Gene Product
Arabidopsis thaliana AT2G37975   Yos1-like protein
Arabidopsis thaliana AT3G54085   Yos1-like protein
Brugia malayi Bm1_02655   RIKEN cDNA 1110057H19
Caenorhabditis elegans CELE_W09G3.8   Protein W09G3.8
Dictyostelium discoideum DDB_G0279479   hypothetical protein
Drosophila melanogaster Dmel_CG32069   CG32069 gene product from transcript CG32069-RA
Echinococcus granulosus EgrG_000821500   immediate early response 3 interacting protein
Entamoeba histolytica EHI_178640   Yos1-like domain-containing protein
Echinococcus multilocularis EmuJ_000821500   immediate early response 3 interacting protein
Homo sapiens 51124   immediate early response 3 interacting protein 1
Leishmania braziliensis LbrM.34.2441   hypothetical protein, conserved
Leishmania donovani LdBPK_352550.1   Yos1-like, putative
Leishmania infantum LinJ.35.2550   hypothetical protein, conserved
Leishmania major LmjF.35.2510   hypothetical protein, conserved
Leishmania mexicana LmxM.34.2510   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_08563   hypothetical protein
Loa Loa (eye worm) LOAG_07117   hypothetical protein
Mus musculus ENSMUSG00000090000   immediate early response 3 interacting protein 1
Oryza sativa 4332733   Os03g0331900
Oryza sativa 9267898   Os09g0326850
Saccharomyces cerevisiae YER074W-A   Yos1p
Schistosoma japonicum Sjp_0048830   IPR013880,Yos1-like,domain-containing
Trypanosoma brucei gambiense Tbg972.9.8290   hypothetical protein, conserved
Trypanosoma brucei Tb927.9.13310   Yos1-like, putative
Trypanosoma congolense TcIL3000_9_5640   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.510747.114   Yos1-like, putative
Trypanosoma cruzi TcCLB.510657.120   Yos1-like, putative
Toxoplasma gondii TGME49_288900   Yos1 family protein

Essentiality

EgrG_000821500 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb09.211.4155 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb09.211.4155 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb09.211.4155 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb09.211.4155 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
YER074W-A Saccharomyces cerevisiae inviable yeastgenome
TGME49_288900 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EgrG_000821500 (Echinococcus granulosus), immediate early response 3 interacting protein
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