Detailed view for EgrG_000977300

Basic information

TDR Targets ID: 594523
Echinococcus granulosus, serine protease HTRA2 mitochondrial
Source Database / ID:  GeneDB

pI: 7.0798 | Length (AA): 492 | MW (Da): 53310 | Paralog Number: 3

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13180   PDZ domain
PF13365   Trypsin-like peptidase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  
GO:0004252   serine-type endopeptidase activity  
GO:0006508   proteolysis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
121 489 5m3o (A) 140 455 38.00 0 1 0.7988 0.88
129 484 5m3n (A) 148 450 49.00 0 1 0.960677 0.11
423 480 2uzc (A) 26 86 26.00 0 1 0.509886 -1.06
424 481 2fne (A) 1985 2046 29.00 0 1 0.501886 -0.85

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129666)

Species Accession Gene Product
Arabidopsis thaliana AT1G01510   C-terminal binding protein AN
Brugia malayi Bm1_40340   C-terminal binding protein
Caenorhabditis elegans CELE_F49E10.5   Protein CTBP-1, isoform A
Drosophila melanogaster Dmel_CG7583   C-terminal Binding Protein
Echinococcus granulosus EgrG_000816400   Zinc finger C2CH type
Echinococcus granulosus EgrG_000977300   serine protease HTRA2 mitochondrial
Echinococcus granulosus EgrG_000977100   V type proton ATPase subunit C 1 A
Echinococcus granulosus EgrG_001081400   subfamily S1B unassigned peptidase S01 family
Echinococcus multilocularis EmuJ_000977300   serine protease HTRA2, mitochondrial
Echinococcus multilocularis EmuJ_000977100   V type proton ATPase subunit C 1 A
Echinococcus multilocularis EmuJ_001081400   subfamily S1B unassigned peptidase (S01 family)
Echinococcus multilocularis EmuJ_000816400   Zinc finger, C2CH type
Homo sapiens 1488   C-terminal binding protein 2
Homo sapiens ENSG00000159692   C-terminal binding protein 1
Loa Loa (eye worm) LOAG_02007   hypothetical protein
Mus musculus ENSMUSG00000037373   C-terminal binding protein 1
Mus musculus ENSMUSG00000030970   C-terminal binding protein 2
Oryza sativa 4349220   Os10g0533000
Oryza sativa 4331469   Os03g0126100
Schistosoma japonicum Sjp_0077250   ko:K04496 C-terminal binding protein, putative
Schistosoma japonicum Sjp_0214220   ko:K01535 H+-transporting ATPase [EC3.6.3.6], putative
Schistosoma mansoni Smp_162090   subfamily S1B unassigned peptidase (S01 family)
Schmidtea mediterranea mk4.001080.00   C-terminal-binding protein 1
Schmidtea mediterranea mk4.007505.00  
Trichomonas vaginalis TVAG_299140   2-hydroxyacid dehydrogenase, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens C-terminal binding protein 2 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0117 0.4384 0.4356
0.001 0.5 0.5
0.0395 0.8919 0.8919

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EgrG_000977300 (Echinococcus granulosus), serine protease HTRA2 mitochondrial
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