Detailed view for CaO19.2743

Basic information

TDR Targets ID: 644720
Candida albicans, one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp
Source Database / ID:  KEGG  

pI: 7.3384 | Length (AA): 606 | MW (Da): 70378 | Paralog Number: 3

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02373   JmjC domain, hydroxylase
PF02375   jmjN domain
PF13771   PHD-like zinc-binding domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
15 328 3opt (A) 7 341 56.00 0 1 1.19485 -0.85
17 377 5fjk (A) 11 345 35.00 0 1 0.95151 -0.37
22 342 5phl (A) 18 312 40.00 0 1 0.962403 -0.61
22 373 2p5b (B) 14 337 41.00 0 1 1.02256 -0.5

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127917)

Species Accession Gene Product
Brugia malayi Bm1_43520   jmjC domain containing protein
Candida albicans CaO19.2730   one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp
Candida albicans CaO19.10257   one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp
Candida albicans CaO19.2743   one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp
Candida albicans CaO19.10244   one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp
Caenorhabditis elegans CELE_Y48B6A.11   Protein JMJD-2
Drosophila melanogaster Dmel_CG33182   Histone demethylase 4B
Drosophila melanogaster Dmel_CG15835   Histone demethylase 4A
Echinococcus granulosus EgrG_000451700   Transcription factor JmjC domain containing protein
Echinococcus granulosus EgrG_000704100   jumonji domain containing protein
Echinococcus multilocularis EmuJ_000704100   jumonji domain containing protein
Echinococcus multilocularis EmuJ_000451700   Transcription factor, JmjC domain containing protein
Homo sapiens ENSG00000066135   lysine (K)-specific demethylase 4A
Homo sapiens ENSG00000274527   lysine (K)-specific demethylase 4C
Homo sapiens ENSG00000127663   lysine (K)-specific demethylase 4B
Loa Loa (eye worm) LOAG_08011   jmjC domain-containing protein
Loa Loa (eye worm) LOAG_10404   hypothetical protein
Mus musculus ENSMUSG00000033326   lysine (K)-specific demethylase 4A
Mus musculus ENSMUSG00000024201   lysine (K)-specific demethylase 4B
Mus musculus ENSMUSG00000028397   lysine (K)-specific demethylase 4C
Plasmodium yoelii PY07244   hypothetical protein
Saccharomyces cerevisiae YER169W   Rph1p
Schistosoma japonicum Sjp_0317710   expressed protein
Schistosoma japonicum Sjp_0110550   Probable JmjC domain-containing histone demethylation protein 3B, putative
Schistosoma japonicum Sjp_0304290   expressed protein
Schistosoma japonicum Sjp_0098260   JmjC domain-containing histone demethylation protein 3C, putative
Schistosoma mansoni Smp_132170   jumonji domain containing protein
Schmidtea mediterranea mk4.000530.02   Lysine-specific demethylase 4
Schmidtea mediterranea mk4.000117.06   Lysine-specific demethylase 4
Schmidtea mediterranea mk4.000117.05   Lysine-specific demethylase 4
Schmidtea mediterranea mk4.000530.01   Lysine-specific demethylase 4

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens lysine (K)-specific demethylase 4C Compounds References
Homo sapiens lysine (K)-specific demethylase 4A Compounds References
Homo sapiens lysine (K)-specific demethylase 4B Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier CaO19.2743 (Candida albicans), one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp
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