Detailed view for CaO19.3934

Basic information

TDR Targets ID: 645290
Candida albicans, likely arginase similar to S. cerevisiae CAR1 (YPL111W) involved in arginine catabolism to ornithine
Source Database / ID:  KEGG  

pI: 4.8782 | Length (AA): 317 | MW (Da): 34329 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00491   Arginase family

Gene Ontology

Mouse over links to read term descriptions.
GO:0016813   hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines  
GO:0004053   arginase activity  
GO:0046872   metal ion binding  
GO:0006525   arginine metabolic process  

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 316 5ynl (A) 1 318 51.00 0.00000083 1 1.52345 -0.98
12 317 5hj9 (A) 13 320 58.00 0 1 1.8212 -1.87

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128245)

Species Accession Gene Product
Candida albicans CaO19.3934   likely arginase similar to S. cerevisiae CAR1 (YPL111W) involved in arginine catabolism to ornithine
Candida albicans CaO19.11416   likely arginase similar to S. cerevisiae CAR1 (YPL111W) involved in arginine catabolism to ornithine
Caenorhabditis elegans CELE_T21F4.1   Protein T21F4.1, isoform B
Dictyostelium discoideum DDB_G0289195   arginase/agmatinase/formiminoglutamase family protein
Drosophila melanogaster Dmel_CG18104   arginase
Echinococcus granulosus EgrG_000730300   3'partial|arginase 2 mitochondrial
Echinococcus granulosus EgrG_000650700   arginase 2 mitochondrial
Entamoeba histolytica EHI_152330   Arginase, putative
Echinococcus multilocularis EmuJ_000730300  
Echinococcus multilocularis EmuJ_000650700   arginase 2, mitochondrial
Homo sapiens ENSG00000081181   arginase 2
Homo sapiens ENSG00000118520   arginase 1
Leishmania braziliensis LbrM.34.1400   arginase
Leishmania donovani LdBPK_351490.1   arginase
Leishmania infantum LinJ.35.1490   arginase
Leishmania major LmjF.35.1480   arginase
Leishmania mexicana LmxM.34.1480   arginase
Mus musculus ENSMUSG00000019987   arginase, liver
Mus musculus ENSMUSG00000021125   arginase type II
Plasmodium berghei PBANKA_0414800   arginase
Plasmodium falciparum PF3D7_0906500   arginase
Plasmodium knowlesi PKNH_0704300   arginase, putative
Plasmodium vivax PVX_098770   arginase, putative
Plasmodium yoelii PY03443   arginase
Plasmodium yoelii PY05019   arginase
Saccharomyces cerevisiae YPL111W   arginase
Schistosoma japonicum Sjp_0215170   ko:K01476 arginase [EC3.5.3.1], putative
Schistosoma mansoni Smp_059980   arginase
Schmidtea mediterranea mk4.023499.02   Arginase
Schmidtea mediterranea mk4.014767.00   Arginase
Schmidtea mediterranea mk4.000920.04   Arginase
Trichomonas vaginalis TVAG_025140   Arginase, putative
Trichomonas vaginalis TVAG_126050   conserved hypothetical protein
Trichomonas vaginalis TVAG_132290   conserved hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Leishmania amazonensis Arginase Compounds References
Bos taurus Arginase-1 Compounds References
Homo sapiens arginase 1 Compounds References
Rattus norvegicus Arginase-1 Compounds References
Homo sapiens arginase 2 Compounds References
Plasmodium falciparum Arginase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier CaO19.3934 (Candida albicans), likely arginase similar to S. cerevisiae CAR1 (YPL111W) involved in arginine catabolism to ornithine
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