Detailed view for CaO19.5089

Basic information

TDR Targets ID: 645358
Candida albicans, telomerase reverse transcriptase
Source Database / ID:  KEGG  

pI: 9.9516 | Length (AA): 867 | MW (Da): 100861 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00078   Reverse transcriptase (RNA-dependent DNA polymerase)
PF12009   Telomerase ribonucleoprotein complex - RNA binding domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0003964   RNA-directed DNA polymerase activity  
GO:0003721   telomeric template RNA reverse transcriptase activity  
GO:0003677   DNA binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
10 147 5npt (A) 2 142 22.00 0 0.91 0.28747 -0.65
13 147 5npt (A) 5 142 30.00 0.36 0.99 0.313009 -0.37
170 382 4lmo (A) 322 542 21.00 0 1 0.489975 -0.29
177 394 2r4g (A) 263 519 20.00 0 1 0.404742 -0.41

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131652)

Species Accession Gene Product
Arabidopsis thaliana AT5G16850   telomerase reverse transcriptase
Babesia bovis BBOV_I004800   conserved hypothetical protein
Brugia malayi Bm1_37945   Telomerase reverse transcriptase
Candida albicans CaO19.12555   telomerase reverse transcriptase
Candida albicans CaO19.5089   telomerase reverse transcriptase
Dictyostelium discoideum DDB_G0293918   hypothetical protein
Homo sapiens ENSG00000164362   telomerase reverse transcriptase
Mus musculus ENSMUSG00000021611   telomerase reverse transcriptase
Oryza sativa 4352024   Os12g0293100
Onchocerca volvulus OVOC4294   Telomerase reverse transcriptase homolog
Saccharomyces cerevisiae YLR318W   Est2p
Theileria parva TP03_0519   hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens telomerase reverse transcriptase Compounds References
Rattus norvegicus Telomerase reverse transcriptase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier CaO19.5089 (Candida albicans), telomerase reverse transcriptase
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