Detailed view for CaO19.11321

Basic information

TDR Targets ID: 645902
Candida albicans, protein kinase
Source Database / ID:  KEGG  

pI: 6.4407 | Length (AA): 1408 | MW (Da): 155941 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 241 4o5j (A) 84 326 9.00 0 0 0.207255 -0.26
270 727 4mvf (A) 67 403 33.00 0 1 -0.0419159 1.49
272 631 6ccf (A) 125 411 48.00 0 1 0.322482 0.75
438 472 2x7g (A) 202 237 51.00 0.69 0.3 0.442258 0.71
634 747 2aao (A) 23 127 21.00 0.29 0.32 0.188766 -0.54

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127880)

Species Accession Gene Product
Arabidopsis thaliana AT3G45240   serine/threonine-protein kinase GRIK1
Arabidopsis thaliana AT5G60550   geminivirus rep interacting kinase 2
Brugia malayi Bm1_19355   Protein kinase domain containing protein
Candida albicans CaO19.11321   protein kinase
Candida albicans CaO19.3840   protein kinase
Caenorhabditis elegans CELE_C05H8.1   Protein CKK-1, isoform A
Dictyostelium discoideum DDB_G0279405   CAMKK family protein kinase
Drosophila melanogaster Dmel_CG17698   CG17698 gene product from transcript CG17698-RF
Echinococcus multilocularis EmuJ_001199300   calcium:calmodulin dependent protein kinase
Homo sapiens ENSG00000110931   calcium/calmodulin-dependent protein kinase kinase 2, beta
Homo sapiens ENSG00000004660   calcium/calmodulin-dependent protein kinase kinase 1, alpha
Loa Loa (eye worm) LOAG_15906   hypothetical protein
Loa Loa (eye worm) LOAG_13276   CAMKK/META protein kinase
Loa Loa (eye worm) LOAG_12514   hypothetical protein
Loa Loa (eye worm) LOAG_12516   hypothetical protein
Mus musculus ENSMUSG00000020785   calcium/calmodulin-dependent protein kinase kinase 1, alpha
Mus musculus ENSMUSG00000029471   calcium/calmodulin-dependent protein kinase kinase 2, beta
Oryza sativa 4333884   Os03g0711300
Saccharomyces cerevisiae YER129W   Sak1p
Saccharomyces cerevisiae YGL179C   Tos3p
Schmidtea mediterranea mk4.008823.01  
Schmidtea mediterranea mk4.011555.01   Ca2+/calmodulin//Q-dependent protein kinase kinase
Schmidtea mediterranea mk4.005451.00  
Schmidtea mediterranea mk4.021989.00   Ca2+/calmodulin//Q-dependent protein kinase kinase
Trichomonas vaginalis TVAG_039920   AGC family protein kinase
Trichomonas vaginalis TVAG_107700   CAMK family protein kinase
Trichomonas vaginalis TVAG_090890   CAMK family protein kinase
Trichomonas vaginalis TVAG_388830   CAMK family protein kinase
Trichomonas vaginalis TVAG_224480   CAMK family protein kinase
Trichomonas vaginalis TVAG_113080   CAMK family protein kinase
Trichomonas vaginalis TVAG_351900   AGC family protein kinase
Trichomonas vaginalis TVAG_322730   AGC family protein kinase
Trichomonas vaginalis TVAG_170420   AGC family protein kinase
Trichomonas vaginalis TVAG_414110   CAMK family protein kinase
Trichomonas vaginalis TVAG_227050   AGC family protein kinase
Trichomonas vaginalis TVAG_241790   CAMK family protein kinase
Trichomonas vaginalis TVAG_352570   CAMK family protein kinase
Trichomonas vaginalis TVAG_219250   CAMK family protein kinase

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens calcium/calmodulin-dependent protein kinase kinase 1, alpha Compounds References
Homo sapiens calcium/calmodulin-dependent protein kinase kinase 2, beta Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Patiria pectinifera Cdc2 300 aa 20.8% 375 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 24.1% 374 aa Compounds References
Rattus norvegicus Mitogen-activated protein kinase 1 358 aa 23.0% 431 aa Compounds References
Bos taurus Glycogen synthase kinase-3 beta splice variant X1 419 aa 25.6% 360 aa Compounds References
Schizosaccharomyces pombe 972h- Casein kinase II subunit alpha 332 aa 21.7% 383 aa Compounds References
Rattus norvegicus c-Jun N-terminal kinase 3 464 aa 23.1% 394 aa Compounds References
Rattus norvegicus Mitogen-activated protein kinase 8 411 aa 24.0% 392 aa Compounds References
Rattus norvegicus Glycogen synthase kinase-3 beta 420 aa 25.6% 360 aa Compounds References
Rattus norvegicus MAP kinase p38 alpha 360 aa 24.1% 432 aa Compounds References
Sus scrofa Glycogen synthase kinase 3 beta 420 aa 25.6% 360 aa Compounds References
Xenopus laevis Aurora kinase B-A 361 aa 25.9% 363 aa Compounds References
Xenopus laevis Aurora kinase B-B 368 aa 26.2% 363 aa Compounds References
Bos taurus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 22.8% 311 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 24.0% 384 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier CaO19.11321 (Candida albicans), protein kinase
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