pI: 9.7207 |
Length (AA): 361 |
MW (Da): 40281 |
Paralog Number:
3
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_127583)
Species | Accession | Gene Product |
---|---|---|
Candida albicans | CaO19.10583 | D-amino acid oxidase |
Candida albicans | CaO19.8559 | putative d-amino acid oxidase |
Candida albicans | CaO19.3065 | D-amino acid oxidase |
Candida albicans | CaO19.944 | putative d-amino acid oxidase |
Caenorhabditis elegans | CELE_F18E3.7 | Protein DDO-2, isoform B |
Caenorhabditis elegans | CELE_Y69A2AR.5 | Protein DAAO-1 |
Caenorhabditis elegans | CELE_C47A10.5 | Protein DDO-1, isoform B |
Dictyostelium discoideum | DDB_G0273783 | D-amino-acid:oxygen oxidoreductase |
Dictyostelium discoideum | DDB_G0273291 | D-amino-acid:oxygen oxidoreductase |
Drosophila melanogaster | Dmel_CG12338 | CG12338 gene product from transcript CG12338-RB |
Drosophila melanogaster | Dmel_CG11236 | CG11236 gene product from transcript CG11236-RA |
Homo sapiens | ENSG00000203797 | D-aspartate oxidase |
Homo sapiens | ENSG00000110887 | D-amino-acid oxidase |
Loa Loa (eye worm) | LOAG_03943 | hypothetical protein |
Mycobacterium leprae | ML2011 | PROBABLE D-AMINO ACID OXIDASE AAO |
Mus musculus | ENSMUSG00000042096 | D-amino acid oxidase |
Mus musculus | ENSMUSG00000063428 | D-aspartate oxidase |
Mycobacterium tuberculosis | Rv1905c | Probable D-amino acid oxidase Aao |
Mycobacterium ulcerans | MUL_2926 | D-amino acid oxidase Aao |
Schistosoma japonicum | Sjp_0008140 | ko:K00272 D-aspartate oxidase [EC1.4.3.1], putative |
Schistosoma mansoni | Smp_170430 | d-amino acid oxidase |
Schmidtea mediterranea | mk4.003324.03 | D-amino-acid oxidase |
Schmidtea mediterranea | mk4.000344.03 | D-amino-acid oxidase |
Schmidtea mediterranea | mk4.000344.09 | D-amino-acid oxidase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_F18E3.7 | Caenorhabditis elegans | embryonic lethal | wormbase |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Sus scrofa | D-amino-acid oxidase | Compounds | References |
Rattus norvegicus | D-aspartate oxidase | Compounds | References |
Homo sapiens | D-aspartate oxidase | Compounds | References |
Rattus norvegicus | D-amino-acid oxidase | Compounds | References |
Homo sapiens | D-amino-acid oxidase | Compounds | References |
Mus musculus | D-aspartate oxidase | Compounds | References |
Mus musculus | D-amino acid oxidase | Compounds | References |
Bos taurus | D-aspartate oxidase | Compounds | References |