Detailed view for CaO19.13137

Basic information

TDR Targets ID: 647917
Candida albicans, secretory aspartyl proteinase SAP1p
Source Database / ID:  KEGG  

pI: 4.9884 | Length (AA): 391 | MW (Da): 41602 | Paralog Number: 15

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00026   Eukaryotic aspartyl protease

Gene Ontology

Mouse over links to read term descriptions.
GO:0004190   aspartic-type endopeptidase activity  
GO:0006508   proteolysis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130378)

Species Accession Gene Product
Candida albicans CaO19.12988   secretory aspartyl proteinase SAP6p
Candida albicans CaO19.11320   secretory aspartyl proteinase SAP10p, related to SAP9p
Candida albicans CaO19.5542   secretory aspartyl proteinase SAP6p
Candida albicans CaO19.5714   secretory aspartyl proteinase SAP1p
Candida albicans CaO19.6001   secretory aspartyl proteinase SAP3p
Candida albicans CaO19.13422   secretory aspartyl proteinase SAP3p
Candida albicans CaO19.11193   secretory aspartyl proteinase SAP2p
Candida albicans CaO19.5716   secretory aspartyl proteinase SAP4p
Candida albicans CaO19.7872   secretory aspartyl proteinase SAP8p
Candida albicans CaO19.3708   secretory aspartyl proteinase SAP2p
Candida albicans CaO19.13139   secretory aspartyl proteinase SAP4p
Candida albicans CaO19.242   secretory aspartyl proteinase SAP8p
Candida albicans CaO19.13137   secretory aspartyl proteinase SAP1p
Candida albicans CaO19.3839   secretory aspartyl proteinase SAP10p, related to SAP9p
Candida albicans CaO19.5585   secretory aspartyl proteinase SAP5p
Candida albicans CaO19.13032   secretory aspartyl proteinase SAP5p
Saccharomyces cerevisiae YLR121C   Yps3p

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Candida albicans secretory aspartyl proteinase SAP2p Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Bos taurus Cathepsin D 390 aa 29.0% 386 aa Compounds References
Penicillium janthinellum Penicillopepsin 323 aa 27.5% 338 aa Compounds References
Sus scrofa Pepsin A 385 aa 31.1% 331 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

  • ChEMBL
  • Inhibition of SAP1-dependent growth in Candida albicans SAP2MS4B expressing SAP1ex4A at 100 uM incubated in YCB-BSA medium
  • ChEMBL
  • Inhibition of SAP1-dependent growth in Candida albicans SAP2MS4B expressing SAP1ex4A at 7.3 uM incubated in YCB-BSA medium

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier CaO19.13137 (Candida albicans), secretory aspartyl proteinase SAP1p
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