Detailed view for CaO19.4589

Basic information

TDR Targets ID: 648223
Candida albicans, likely Flavin containing amine oxidoreductase
Source Database / ID:  KEGG  

pI: 6.5917 | Length (AA): 477 | MW (Da): 54615 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01593   Flavin containing amine oxidoreductase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016491   oxidoreductase activity  
GO:0055114   oxidation reduction  

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131236)

Species Accession Gene Product
Arabidopsis thaliana AT1G62830   Lysine-specific histone demethylase 1-1
Arabidopsis thaliana AT3G10390   lysine-specific histone demethylase 1 homolog 3
Arabidopsis thaliana AT3G13682   lysine-specific histone demethylase 1-like 2
Brugia malayi Bm1_14900   amine oxidase, flavin-containing family protein
Candida albicans CaO19.4589   likely Flavin containing amine oxidoreductase
Candida albicans CaO19.12058   likely Flavin containing amine oxidoreductase
Caenorhabditis elegans CELE_R13G10.2   Protein AMX-1
Homo sapiens ENSG00000165097   lysine (K)-specific demethylase 1B
Loa Loa (eye worm) LOAG_10384   hypothetical protein
Loa Loa (eye worm) LOAG_14900   hypothetical protein
Mus musculus ENSMUSG00000038080   lysine (K)-specific demethylase 1B
Oryza sativa 4344644   Os08g0143400
Oryza sativa 4336650   Os04g0560300
Oryza sativa 4330771   Os02g0755200
Schmidtea mediterranea mk4.016798.03   Amine oxidase family member 1
Schmidtea mediterranea mk4.016798.02  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens lysine (K)-specific demethylase 1B Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier CaO19.4589 (Candida albicans), likely Flavin containing amine oxidoreductase
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