Detailed view for CaO19.7131

Basic information

TDR Targets ID: 648382
Candida albicans, one of two potential gamma-butyrobetaine hydroxylase genes, last step in carnitine biosynthesis, EC 1.14.11.1
Source Database / ID:  KEGG  

pI: 6.5879 | Length (AA): 407 | MW (Da): 46807 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02668   Taurine catabolism dioxygenase TauD, TfdA family

Gene Ontology

Mouse over links to read term descriptions.
GO:0016491   oxidoreductase activity  
GO:0055114   oxidation reduction  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
21 109 2l6n (A) 19 102 18.00 0 0.24 0.364573 -0.54
21 406 3n6w (A) 13 384 22.00 0 1 1.0873 -0.07
39 405 4c5w (A) 32 383 28.00 0 1 1.17622 -0.02

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129640)

Species Accession Gene Product
Candida albicans CaJ7_0511   hypothetical protein
Candida albicans CaO19.7131   one of two potential gamma-butyrobetaine hydroxylase genes, last step in carnitine biosynthesis, EC 1.14.11.1
Caenorhabditis elegans CELE_D2089.5   Protein GBH-1
Drosophila melanogaster Dmel_CG14630   CG14630 gene product from transcript CG14630-RA
Drosophila melanogaster Dmel_CG10814   CG10814 gene product from transcript CG10814-RA
Drosophila melanogaster Dmel_CG5321   CG5321 gene product from transcript CG5321-RB
Homo sapiens ENSG00000129151   butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
Mus musculus 170442   butyrobetaine (gamma), 2-oxoglutarate dioxygenase 1 (gamma-butyrobetaine hydroxylase)
Saccharomyces cerevisiae YHL021C   Aim17p

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Pseudomonas sp. (strain AK-1) Gamma-butyrobetaine dioxygenase 383 aa 29.2% 394 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier CaO19.7131 (Candida albicans), one of two potential gamma-butyrobetaine hydroxylase genes, last step in carnitine biosynthesis, EC 1.14.11.1
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