Detailed view for CaO19.12534

Basic information

TDR Targets ID: 649987
Candida albicans, likely protein kinase/endoribonuclease similar to S. cerevisiae IRE1 (YHR079C) multifunctional serine-threonine kinase, ER trans
Source Database / ID:  KEGG  

pI: 5.7041 | Length (AA): 1223 | MW (Da): 139302 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain
PF06479   Ribonuclease 2-5A

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  
GO:0004672   protein kinase activity  
GO:0004540   ribonuclease activity  
GO:0005524   ATP binding  
GO:0006468   protein amino acid phosphorylation  
GO:0006397   mRNA processing  

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
68 387 2be1 (A) 112 432 41.00 0 1 0.596952 -0.13
763 1223 2rio (A) 11 432 47.00 0 1 0.633642 0.23
766 1222 3fbv (A) 671 1112 55.00 0 1 0.894971 -0.29
857 930 2x7g (A) 194 543 36.00 0.099 0.53 0.351007 -0.31

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128843)

Species Accession Gene Product
Arabidopsis thaliana AT2G17520   serine/threonine-protein kinase/endoribonuclease IRE1a
Arabidopsis thaliana AT5G24360   protein inositol requiring 1-1
Brugia malayi Bm1_25785   Ribonuclease 2-5A family protein
Candida albicans CaO19.12534   likely protein kinase/endoribonuclease similar to S. cerevisiae IRE1 (YHR079C) multifunctional serine-threonine kinase, ER trans
Candida albicans CaO19.5068   likely protein kinase/endoribonuclease similar to S. cerevisiae IRE1 (YHR079C) multifunctional serine-threonine kinase, ER trans
Caenorhabditis elegans CELE_C41C4.4   Protein IRE-1, isoform B
Dictyostelium discoideum DDB_G0267650   IRE family protein kinase
Drosophila melanogaster Dmel_CG4583   Inositol-requiring enzyme-1
Echinococcus granulosus EgrG_000182000   serine:threonine protein kinase:endoribonuclease
Entamoeba histolytica EHI_068350   protein kinase, putative
Entamoeba histolytica EHI_075540   protein kinase, putative
Echinococcus multilocularis EmuJ_000182000   serine:threonine protein kinase:endoribonuclease
Homo sapiens ENSG00000178607   endoplasmic reticulum to nucleus signaling 1
Homo sapiens ENSG00000134398   endoplasmic reticulum to nucleus signaling 2
Loa Loa (eye worm) LOAG_00603   IRE protein kinase
Mus musculus ENSMUSG00000030866   endoplasmic reticulum (ER) to nucleus signalling 2
Mus musculus 78943   endoplasmic reticulum (ER) to nucleus signalling 1
Oryza sativa 4343198   Os07g0471000
Saccharomyces cerevisiae YHR079C   Ire1p
Schmidtea mediterranea mk4.001731.01  
Schmidtea mediterranea mk4.001617.00   Serine/threonine-protein kinase/endoribonuclease IRE1

Essentiality

CaO19.12534 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C41C4.4 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens endoplasmic reticulum to nucleus signaling 1 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Mitogen-activated protein kinase 1 358 aa 25.1% 287 aa Compounds References
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 31.4% 172 aa Compounds References
Xenopus laevis Aurora kinase B-A 361 aa 21.9% 329 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 21.9% 356 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier CaO19.12534 (Candida albicans), likely protein kinase/endoribonuclease similar to S. cerevisiae IRE1 (YHR079C) multifunctional serine-threonine kinase, ER trans
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