Detailed view for CaO19.147
Basic information
Candida albicans, similar to C terminus of S. cerevisiae YAK1 (YJL141C) serine-threonine protein kinase
Source Database / ID: KEGG
pI: 8.9223 |
Length (AA): 379 |
MW (Da): 43756 |
Paralog Number:
3
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Network
Pfam domains
Gene Ontology
GO:0004672 protein kinase activity
GO:0006468 protein amino acid phosphorylation
Metabolic Pathways
Structural information
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
| Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
|---|---|---|---|---|---|---|---|---|---|
| 2 | 379 | 6b3e (C) | 729 | 1028 | 27.00 | 0 | 1 | 0.897861 | 0.73 |
| 2 | 235 | 2x7g (A) | 94 | 638 | 37.00 | 0 | 1 | 0.964714 | -0.54 |
| 4 | 371 | 4ylk (A) | 163 | 479 | 42.00 | 0 | 1 | 1.28098 | -0.17 |
| 5 | 203 | 4tnd (A) | 191 | 390 | 30.00 | 0.0000000032 | 1 | 0.898366 | -0.6 |
Help me make sense of these data.
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Expression
Orthologs
Ortholog group members (OG5_129272)
| Species | Accession | Gene Product |
|---|---|---|
| Brugia malayi | Bm1_21245 | Homeodomain interacting protein kinase protein 1 |
| Candida albicans | CaO19.147 | similar to C terminus of S. cerevisiae YAK1 (YJL141C) serine-threonine protein kinase |
| Candida albicans | CaO19.148 | hypothetical protein |
| Candida albicans | CaO19.7787 | similar to C terminus of S. cerevisiae YAK1 (YJL141C) serine-threonine protein kinase |
| Candida albicans | CaO19.7788 | hypothetical protein |
| Caenorhabditis elegans | CELE_F20B6.8 | Protein HPK-1, isoform C |
| Drosophila melanogaster | Dmel_CG17090 | homeodomain interacting protein kinase |
| Echinococcus granulosus | EgrG_001067800 | homeodomain interacting protein kinase 3 |
| Entamoeba histolytica | EHI_153120 | protein kinase domain containing protein |
| Echinococcus multilocularis | EmuJ_001067800 | homeodomain interacting protein kinase 3 |
| Homo sapiens | ENSG00000163349 | homeodomain interacting protein kinase 1 |
| Homo sapiens | ENSG00000064393 | homeodomain interacting protein kinase 2 |
| Homo sapiens | ENSG00000110422 | homeodomain interacting protein kinase 3 |
| Loa Loa (eye worm) | LOAG_04459 | CMGC/DYRK/HIPK protein kinase |
| Mus musculus | ENSMUSG00000027177 | homeodomain interacting protein kinase 3 |
| Mus musculus | ENSMUSG00000061436 | homeodomain interacting protein kinase 2 |
| Mus musculus | ensembl-mmu:ENSMUSG00000008730 | homeodomain interacting protein kinase 1 |
| Schistosoma japonicum | Sjp_0106630 | ko:K08826 homeodomain interacting protein kinase, putative |
| Schistosoma japonicum | Sjp_0013650 | expressed protein |
| Schistosoma mansoni | Smp_000720 | serine/threonine protein kinase |
| Schmidtea mediterranea | mk4.001360.04 | Homeodomain-interacting protein kinase 4 |
Essentiality
Phenotypes and Validation (curated)
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Annotated validation
Associated compounds / Druggability
Known modulators for this target
Predicted associations
By orthology with druggable targets
| Species | Known druggable target | Linked compounds | Reference |
|---|---|---|---|
| Homo sapiens | homeodomain interacting protein kinase 1 | Compounds | References |
| Homo sapiens | homeodomain interacting protein kinase 3 | Compounds | References |
| Homo sapiens | homeodomain interacting protein kinase 2 | Compounds | References |
By sequence similarity to non orthologous druggable targets
| Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
|---|---|---|---|---|---|---|
| Rattus norvegicus | Jak1 protein | 210 aa | 25.0% | 172 aa | Compounds | References |
| Sus scrofa | Casein kinase I isoform alpha | 125 aa | 30.1% | 123 aa | Compounds | References |
| Oryctolagus cuniculus | Cyclin-dependent kinase 4 | 189 aa | 33.7% | 175 aa | Compounds | References |
| Patiria pectinifera | Cdc2 | 300 aa | 30.0% | 253 aa | Compounds | References |
Obtained from network model
Assayability
Assay information
Reagent availability
Bibliographic References