pI: 4.4182 |
Length (AA): 447 |
MW (Da): 51421 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_129591)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G21060 | COMPASS-like H3K4 histone methylation complex component |
Brugia malayi | Bm1_24845 | Hypothetical WD-repeat protein F21H12.1 in chromosome II |
Candida albicans | CaO19.12843 | similar to S. cerevisiae SWD1 (YAR003W) subunit of the COMPASS histone methyltransferase complex |
Candida albicans | CaO19.5388 | similar to S. cerevisiae SWD1 (YAR003W) subunit of the COMPASS histone methyltransferase complex |
Caenorhabditis elegans | CELE_F21H12.1 | Protein RBBP-5 |
Dictyostelium discoideum | DDB_G0285847 | WD-40 repeat-containing protein |
Drosophila melanogaster | Dmel_CG5585 | CG5585 gene product from transcript CG5585-RA |
Echinococcus granulosus | EgrG_000910100 | wd40 repeat |
Echinococcus multilocularis | EmuJ_000910100 | wd40 repeat |
Homo sapiens | ENSG00000117222 | retinoblastoma binding protein 5 |
Loa Loa (eye worm) | LOAG_07254 | hypothetical protein |
Mus musculus | ENSMUSG00000026439 | retinoblastoma binding protein 5 |
Oryza sativa | 4332006 | Os03g0207900 |
Saccharomyces cerevisiae | YAR003W | Swd1p |
Schistosoma japonicum | Sjp_0004050 | expressed protein |
Schistosoma japonicum | Sjp_0059740 | Retinoblastoma-binding protein 5, putative |
Schistosoma mansoni | Smp_142780 | retinoblastoma binding protein |
Schmidtea mediterranea | mk4.018703.00 | Retinoblastoma-binding protein 5 |
Schmidtea mediterranea | mk4.015190.00 | |
Trichomonas vaginalis | TVAG_150180 | retinoblastoma binding protein, putative |
Trichomonas vaginalis | TVAG_193500 | conserved hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_F21H12.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | retinoblastoma binding protein 5 | Compounds | References |