Detailed view for CaO19.10617

Basic information

TDR Targets ID: 652280
Candida albicans, weak similarity to fungal trichodiene oxygenase, P450 monooxygenase involved in mycotoxin trichothecene biosynthesis, CYP58
Source Database / ID:  KEGG  

pI: 7.7011 | Length (AA): 519 | MW (Da): 60064 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00067   Cytochrome P450

Gene Ontology

Mouse over links to read term descriptions.
GO:0016705   oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen  
GO:0020037   heme binding  
GO:0005506   iron ion binding  
GO:0004497   monooxygenase activity  
GO:0055114   oxidation reduction  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 8 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
10 467 5jlc (A) 20 500 21.00 0 0.95 1.00247 0.61
10 464 4lxj (A) 19 495 21.00 0 0.94 0.980686 0.66
11 464 5jlc (A) 21 497 24.00 0.0000000091 0.98 0.986259 0.75
28 487 6c93 (A) 24 492 20.00 0 1 1.11432 -0.02
37 485 2hi4 (A) 34 500 17.00 0 1 1.07213 -0.21
43 518 3b6h (A) 24 498 15.00 0 1 1.03835 0.19
46 467 1dt6 (A) 31 456 22.00 0 1 0.991102 0.08
275 464 4dvq (A) 300 471 37.00 0 1 0.637589 0.17

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_137847)

Species Accession Gene Product
Candida albicans CaO19.3105   weak similarity to fungal trichodiene oxygenase, P450 monooxygenase involved in mycotoxin trichothecene biosynthesis, CYP58
Candida albicans CaO19.10617   weak similarity to fungal trichodiene oxygenase, P450 monooxygenase involved in mycotoxin trichothecene biosynthesis, CYP58

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Cytochrome P450 3A1 504 aa 24.2% 447 aa Compounds References
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSCA1100) (Aspergillus fumigatus) 14-alpha sterol demethylase Cyp51A 515 aa 22.3% 422 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier CaO19.10617 (Candida albicans), weak similarity to fungal trichodiene oxygenase, P450 monooxygenase involved in mycotoxin trichothecene biosynthesis, CYP58
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