Detailed view for CaO19.99

Basic information

TDR Targets ID: 652477
Candida albicans, one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt

Source Database / ID:  KEGG  

pI: 6.5011 | Length (AA): 377 | MW (Da): 40857 | Paralog Number: 3

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00459   Inositol monophosphatase family

Gene Ontology

Mouse over links to read term descriptions.
GO:0008441   3'(2'),5'-bisphosphate nucleotidase activity  
GO:0046854   phosphoinositide phosphorylation  
GO:0006790   sulfur metabolic process  

Metabolic Pathways

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
41 376 5esy (A) 1 328 35.00 0 1 1.27815 0.26
43 376 1ka1 (A) 3 334 50.00 0 1 1.48104 -1.07
161 210 4n81 (A) 68 121 48.00 0.000017 0.92 0.622026 0.32

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein


No expression data available for this gene


Ortholog group members (OG5_129356)

Species Accession Gene Product
Arabidopsis thaliana AT5G54390   PAP-specific phosphatase HAL2-like protein
Arabidopsis thaliana AT5G63980   bifunctional 3'(2'),5'-bisphosphate nucleotidase and inositol polyphosphate 1-phosphatase
Candida albicans CaO19.105   one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt
Candida albicans CaO19.7752   one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt
Candida albicans CaO19.99   one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt
Candida albicans CaO19.7746   one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt
Cryptosporidium hominis Chro.20197   CysQ protein
Cryptosporidium parvum cgd2_1810   CysQ, sulfite synthesis pathway protein, putative
Chlamydia trachomatis CT_774   3'(2'),5'-bisphosphate nucleotidase CysQ
Dictyostelium discoideum DDB_G0268652   3',5'-bisphosphate nucleotidase
Escherichia coli b4214   3'(2'),5'-bisphosphate nucleotidase
Entamoeba histolytica EHI_193350   3(2),5-bisphosphate nucleotidase, putative
Neospora caninum NCLIV_048810   inositol monophosphatase domain-containing protein, putative
Oryza sativa 4351686   Os12g0183300
Oryza sativa 4351685   Os12g0183200
Oryza sativa 4331065   Os02g0805500
Saccharomyces cerevisiae YOL064C   Met22p
Toxoplasma gondii TGME49_223668   LYAR-type C2HC zinc finger protein
Trichomonas vaginalis TVAG_144580   inositol monophosphatase, putative
Trichomonas vaginalis TVAG_275770   diphosphonucleoside phosphohydrolase, putative
Trichomonas vaginalis TVAG_278540   inositol monophosphatase, putative
Trichomonas vaginalis TVAG_308070   myo inositol monophosphatase, putative


CaO19.99 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b4214 Escherichia coli non-essential goodall
TGME49_223668 Toxoplasma gondii Probably non-essential sidik
TGME49_223668 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site,, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Bos taurus Inositol-1(or 4)-monophosphatase 1 277 aa 22.1% 303 aa Compounds References
Rattus norvegicus Inositol monophosphatase 1 277 aa 22.5% 306 aa Compounds References

Obtained from network model
No druggable targets predicted through repurposing network model


Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier CaO19.99 (Candida albicans), one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt
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