Detailed view for CaO19.11797

Basic information

TDR Targets ID: 654325
Candida albicans, dipeptidyl aminopeptidase B
Source Database / ID:  KEGG  

pI: 5.2569 | Length (AA): 838 | MW (Da): 96336 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00326   Prolyl oligopeptidase family
PF00930   Dipeptidyl peptidase IV (DPP IV) N-terminal region

Gene Ontology

Mouse over links to read term descriptions.
GO:0004252   serine-type endopeptidase activity  
GO:0008236   serine-type peptidase activity  
GO:0006508   proteolysis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
88 834 2ecf (A) 30 740 25.00 0 1 1.06101 0.48
97 833 4a5s (A) 48 763 32.00 0 1 1.22387 -0.13
591 833 3qh4 (A) 67 311 16.00 0 1 0.444576 -0.76
600 833 3fak (A) 64 295 19.00 0 1 0.412836 -0.75
603 752 2hm7 (A) 74 204 34.00 0.17 0.62 0.341398 0.21

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128614)

Species Accession Gene Product
Brugia malayi Bm1_48250   prolyl oligopeptidase family protein
Candida albicans CaO19.4322   dipeptidyl aminopeptidase B
Candida albicans CaO19.11797   dipeptidyl aminopeptidase B
Caenorhabditis elegans CELE_T23F1.7   Protein DPF-1, isoform C
Caenorhabditis elegans CELE_C27C12.7   Protein DPF-2
Drosophila melanogaster Dmel_CG11034   CG11034 gene product from transcript CG11034-RC
Drosophila melanogaster Dmel_CG42280   omega
Echinococcus granulosus EgrG_000297600   dipeptidyl aminopeptidaseprotein
Echinococcus multilocularis EmuJ_000297600   dipeptidyl aminopeptidaseprotein
Homo sapiens ENSG00000197635   dipeptidyl-peptidase 4
Homo sapiens ENSG00000078098   fibroblast activation protein, alpha
Loa Loa (eye worm) LOAG_00435   prolyl oligopeptidase
Mus musculus ENSMUSG00000035000   dipeptidylpeptidase 4
Mus musculus ENSMUSG00000000392   fibroblast activation protein
Onchocerca volvulus OVOC1140   Dipeptidyl peptidase family member 1 homolog
Saccharomyces cerevisiae YHR028C   Dap2p
Schistosoma japonicum Sjp_0033000   ko:K01278 dipeptidyl-peptidase 4, putative
Schistosoma mansoni Smp_057530   subfamily S9B unassigned peptidase (S09 family)
Schmidtea mediterranea mk4.014436.00  
Schmidtea mediterranea mk4.014942.01  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Bos taurus Prolyl endopeptidase FAP Compounds References
Rattus norvegicus Dipeptidyl peptidase IV Compounds References
Mus musculus fibroblast activation protein Compounds References
Mus musculus dipeptidylpeptidase 4 Compounds References
Homo sapiens dipeptidyl-peptidase 4 Compounds References
Sus scrofa Dipeptidyl peptidase IV Compounds References
Homo sapiens fibroblast activation protein, alpha Compounds References
Bos taurus Dipeptidyl peptidase IV Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier CaO19.11797 (Candida albicans), dipeptidyl aminopeptidase B
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