Detailed view for CaO19.9221

Basic information

TDR Targets ID: 654390
Candida albicans, fatty-acyl coenzyme A oxidase similar to C.tropicalis POX4, linked to POX102
Source Database / ID:  KEGG  

pI: 5.7631 | Length (AA): 709 | MW (Da): 78963 | Paralog Number: 5

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00441   Acyl-CoA dehydrogenase, C-terminal domain
PF01756   Acyl-CoA oxidase
PF02770   Acyl-CoA dehydrogenase, middle domain
PF14749   Acyl-coenzyme A oxidase N-terminal

Gene Ontology

Mouse over links to read term descriptions.
GO:0071949   GO:FAD binding  

GO:0016627   oxidoreductase activity, acting on the CH-CH group of donors  
GO:0005777   peroxisome  
GO:0003997   acyl-CoA oxidase activity  
GO:0050660   FAD binding  
GO:0055114   oxidation reduction  
GO:0006635   fatty acid beta-oxidation  
GO:0006631   fatty acid metabolic process  

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
14 702 5ys9 (A) 21 699 32.00 0 1 1.34889 -0.07
15 694 5y9d (A) 8 683 41.00 0 1 1.5185 -0.89
15 693 5ys9 (A) 22 692 45.00 0 1 1.52809 -0.7
19 679 2ddh (A) 4 649 30.00 0 1 1.2434 -0.22

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127307)

Species Accession Gene Product
Arabidopsis thaliana AT2G35690   acyl-CoA oxidase 5
Arabidopsis thaliana AT4G16760   peroxisomal acyl-coenzyme A oxidase 1
Brugia malayi Bm1_15615   Acyl-CoA oxidase family protein
Candida albicans CaO19.1655   fatty-acyl coenzyme A oxidase similar to C.tropicalis POX2, linked to POX104
Candida albicans CaO19.5723   fatty-acyl coA oxidase, peroxisomal beta-oxidation, similar to C.tropicalis POX5
Candida albicans CaO19.9221   fatty-acyl coenzyme A oxidase similar to C.tropicalis POX4, linked to POX102
Candida albicans CaO19.9224   fatty-acyl coenzyme A oxidase similar to C.tropicalis POX2, linked to POX104
Candida albicans CaO19.13146   fatty-acyl coA oxidase, peroxisomal beta-oxidation, similar to C.tropicalis POX5
Candida albicans CaO19.1652   fatty-acyl coenzyme A oxidase similar to C.tropicalis POX4, linked to POX102
Caenorhabditis elegans CELE_F08A8.3   Protein F08A8.3
Caenorhabditis elegans CELE_C48B4.1   Protein C48B4.1
Caenorhabditis elegans CELE_F08A8.2   Protein F08A8.2
Caenorhabditis elegans CELE_F59F4.1   Protein F59F4.1
Caenorhabditis elegans CELE_F08A8.4   Protein F08A8.4
Caenorhabditis elegans CELE_F08A8.1   Protein ACOX-1, isoform B
Dictyostelium discoideum DDB_G0289993   acyl-CoA oxidase
Drosophila melanogaster Dmel_CG9707   acyl-Coenzyme A oxidase at 57D proximal
Drosophila melanogaster Dmel_CG5009   CG5009 gene product from transcript CG5009-RA
Drosophila melanogaster Dmel_CG9709   acyl-Coenzyme A oxidase at 57D distal
Homo sapiens ENSG00000161533   acyl-CoA oxidase 1, palmitoyl
Homo sapiens ENSG00000168306   acyl-CoA oxidase 2, branched chain
Loa Loa (eye worm) LOAG_11263   hypothetical protein
Loa Loa (eye worm) LOAG_09012   acyl-CoA oxidase
Mus musculus ENSMUSG00000021751   acyl-Coenzyme A oxidase 2, branched chain
Mus musculus ENSMUSG00000020777   acyl-Coenzyme A oxidase 1, palmitoyl
Neospora caninum NCLIV_065250   Pc13g14410 protein, related
Oryza sativa 4339846   Os06g0103500
Saccharomyces cerevisiae YGL205W   acyl-CoA oxidase
Toxoplasma gondii TGME49_247500   acyl-CoA dehydrogenase, middle domain-containing protein

Essentiality

CaO19.9221 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F08A8.2 Caenorhabditis elegans slow growth wormbase
CELE_F08A8.3 Caenorhabditis elegans slow growth wormbase
CELE_F08A8.4 Caenorhabditis elegans slow growth wormbase
TGME49_247500 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Rattus norvegicus Palmitoyl-CoA oxidase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier CaO19.9221 (Candida albicans), fatty-acyl coenzyme A oxidase similar to C.tropicalis POX4, linked to POX102
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