pI: 9.6084 |
Length (AA): 105 |
MW (Da): 12183 |
Paralog Number:
5
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_128520)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_35945 | Protein kinase domain containing protein |
Candida albicans | CaO19.9766 | similar to headcase protein |
Candida albicans | CaO19.2221 | similar to headcase protein |
Candida albicans | CaO19.9767 | second casein kinase I-like orf |
Candida albicans | CaO19.2222 | second casein kinase I-like orf |
Candida albicans | CaO19.7001 | casein kinase I-like orf |
Candida albicans | CaO19.1127 | hypothetical protein |
Caenorhabditis elegans | CELE_Y106G6E.6 | Protein CSNK-1 |
Drosophila melanogaster | Dmel_CG6963 | gilgamesh |
Echinococcus granulosus | EgrG_000345900 | casein kinase I gamma |
Echinococcus multilocularis | EmuJ_000345900 | casein kinase I gamma |
Homo sapiens | ENSG00000169118 | casein kinase 1, gamma 1 |
Homo sapiens | ENSG00000151292 | casein kinase 1, gamma 3 |
Homo sapiens | ENSG00000133275 | casein kinase 1, gamma 2 |
Loa Loa (eye worm) | LOAG_08358 | protein kinase domain-containing protein |
Loa Loa (eye worm) | LOAG_04154 | casein kinase |
Mus musculus | ENSMUSG00000032384 | casein kinase 1, gamma 1 |
Mus musculus | ENSMUSG00000003345 | casein kinase 1, gamma 2 |
Mus musculus | ENSMUSG00000073563 | casein kinase 1, gamma 3 |
Saccharomyces cerevisiae | YHR135C | Yck1p |
Saccharomyces cerevisiae | YNL154C | Yck2p |
Schistosoma japonicum | Sjp_0057830 | ko:K08958 casein kinase 1, gamma, putative |
Schistosoma japonicum | Sjp_0102580 | IPR000719,Protein kinase;IPR011009,Protein kinase-like,domain-containing |
Schistosoma mansoni | Smp_180400 | serine/threonine protein kinase |
Schmidtea mediterranea | mk4.002034.02 | Serine/threonine kinase |
Schmidtea mediterranea | mk4.007311.00 | |
Schmidtea mediterranea | mk4.017055.00 | Serine/threonine kinase |
Schmidtea mediterranea | mk4.001439.02 | Serine/threonine kinase |
Schmidtea mediterranea | mk4.010891.00 | Serine/threonine kinase |
Schmidtea mediterranea | mk4.002034.03 | Serine/threonine kinase |
Schmidtea mediterranea | mk4.001887.00 | Serine/threonine kinase |
Schmidtea mediterranea | mk4.014185.00 | |
Schmidtea mediterranea | mk4.002334.00 | |
Schmidtea mediterranea | mk4.024307.00 | Serine/threonine kinase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_Y106G6E.6 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_Y106G6E.6 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_Y106G6E.6 | Caenorhabditis elegans | slow growth | wormbase |
CELE_Y106G6E.6 | Caenorhabditis elegans | sterile | wormbase |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | casein kinase 1, gamma 2 | Compounds | References |
Homo sapiens | casein kinase 1, gamma 1 | Compounds | References |
Homo sapiens | casein kinase 1, gamma 3 | Compounds | References |