Detailed view for CaO19.4707

Basic information

TDR Targets ID: 654654
Candida albicans, one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940)
Source Database / ID:  KEGG  

pI: 5.3478 | Length (AA): 712 | MW (Da): 82842 | Paralog Number: 7

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00149   Calcineurin-like phosphoesterase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016787   hydrolase activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
184 709 5i81 (A) 116 607 20.00 0 1 0.872664 0.09
272 712 5fc1 (A) 29 443 28.00 0 1 0.886482 -0.47
279 627 5kar (A) 22 365 26.00 0 1 0.741269 -0.41
279 709 5ebb (A) 39 443 27.00 0 1 0.876437 -0.51
282 696 5fi9 (A) 201 592 29.00 0 1 0.851965 -0.29
291 371 5hq3 (A) 279 358 34.00 0.13 0.08 0.135864 2.06
532 631 1na0 (A) 13 110 30.00 0.21 0.66 0.498549 -0.62

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128629)

Species Accession Gene Product
Candida albicans CaO19.4707   one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940)
Candida albicans CaO19.8382   one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940)
Candida albicans CaO19.12178   one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940)
Candida albicans CaO19.6037   one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940)
Candida albicans CaO19.936   one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940)
Candida albicans CaO19.8551   one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940)
Candida albicans CaO19.762   one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940)
Candida albicans CaO19.13458   one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940)
Caenorhabditis elegans CELE_B0252.2   Protein ASM-1
Caenorhabditis elegans CELE_ZK455.4   Protein ASM-2
Caenorhabditis elegans CELE_W03G1.7   Protein ASM-3, isoform A
Dictyostelium discoideum DDB_G0293210   metallophosphoesterase domain-containing protein
Dictyostelium discoideum DDB_G0270834   hypothetical protein
Drosophila melanogaster Dmel_CG3376   CG3376 gene product from transcript CG3376-RB
Entamoeba histolytica EHI_040600   Acid sphingomyelinase-like phosphodiesterase, putative
Entamoeba histolytica EHI_118110   Acid sphingomyelinase-like phosphodiesterase, putative
Homo sapiens ENSG00000166311   sphingomyelin phosphodiesterase 1, acid lysosomal
Loa Loa (eye worm) LOAG_10324   hypothetical protein
Mus musculus ENSMUSG00000037049   sphingomyelin phosphodiesterase 1, acid lysosomal

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens sphingomyelin phosphodiesterase 1, acid lysosomal Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier CaO19.4707 (Candida albicans), one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940)
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