Detailed view for CaO19.7451

Basic information

TDR Targets ID: 655018
Candida albicans, similar to S. cerevisiae PAS domain-containing Serine/threonine Kinase
Source Database / ID:  KEGG  

pI: 5.5868 | Length (AA): 1323 | MW (Da): 149216 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain
PF13426   PAS domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 9 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
876 1322 1ym7 (A) 30 454 19.00 0 1 0.369368 0.31
1014 1304 4aw2 (A) 27 319 31.00 0 1 0.446555 0.29
1062 1322 3a99 (A) 36 291 35.00 0 1 0.686879 -1.04
1063 1306 5loh (A) 34 795 37.00 0.0000000019 1 0.215029 0.85
1069 1273 1u59 (A) 343 540 24.00 0.073 0.99 0.298551 0.21
1152 1230 4azs (A) 307 385 28.00 0.093 0.89 0.343713 0.22
1173 1263 4azs (A) 325 443 31.00 0.3 0.98 0.392383 -0.2
1173 1309 2acx (A) 285 431 37.00 0.000000000095 1 0.557153 -0.88
1179 1316 4y8d (A) 151 310 39.00 0.0000000061 1 0.328908 0.11

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131169)

Species Accession Gene Product
Candida albicans CaO19.7451   similar to S. cerevisiae PAS domain-containing Serine/threonine Kinase
Drosophila melanogaster Dmel_CG3105   PAS kinase
Homo sapiens ENSG00000115687   PAS domain containing serine/threonine kinase
Loa Loa (eye worm) LOAG_13268   CAMK/CAMKL/PASK protein kinase
Mus musculus ENSMUSG00000026274   PAS domain containing serine/threonine kinase
Onchocerca volvulus OVOC2488  
Saccharomyces cerevisiae YOL045W   Psk2p
Saccharomyces cerevisiae YAL017W   Psk1p
Schmidtea mediterranea mk4.018907.01  
Schmidtea mediterranea mk4.017704.00  
Schmidtea mediterranea mk4.025522.00  
Schmidtea mediterranea mk4.033670.00  
Schmidtea mediterranea mk4.021254.01  
Schmidtea mediterranea mk4.007929.00  
Schmidtea mediterranea mk4.018417.00  
Schmidtea mediterranea mk4.004890.02  
Schmidtea mediterranea mk4.001918.02  
Schmidtea mediterranea mk4.010770.00  
Schmidtea mediterranea mk4.021254.00  
Schmidtea mediterranea mk4.020163.01  
Schmidtea mediterranea mk4.045355.00  
Schmidtea mediterranea mk4.007470.01  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens PAS domain containing serine/threonine kinase Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 31.1% 177 aa Compounds References
Rattus norvegicus Serine/threonine-protein kinase pim-3 326 aa 34.1% 264 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier CaO19.7451 (Candida albicans), similar to S. cerevisiae PAS domain-containing Serine/threonine Kinase
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