Detailed view for CaO19.4618

Basic information

TDR Targets ID: 655520
Candida albicans, fructose-bisphosphate aldolase
Source Database / ID:  KEGG  

pI: 5.9636 | Length (AA): 359 | MW (Da): 39215 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01116   Fructose-bisphosphate aldolase class-II

Gene Ontology

Mouse over links to read term descriptions.
GO:0016832   aldehyde-lyase activity  
GO:0008270   zinc ion binding  
GO:0004332   fructose-bisphosphate aldolase activity  
GO:0003824   catalytic activity  
GO:0006096   glycolysis  
GO:0005975   carbohydrate metabolic process  

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131639)

Species Accession Gene Product
Candida albicans CaO19.12088   fructose-bisphosphate aldolase
Candida albicans CaO19.4618   fructose-bisphosphate aldolase
Escherichia coli b2925   fructose-bisphosphate aldolase, class II
Mycobacterium leprae ML0286c   Probable fructose bisphosphate aldolase Fba
Mycobacterium tuberculosis Rv0363c   Probable fructose-bisphosphate aldolase Fba
Mycobacterium ulcerans MUL_0103   fructose-bisphosphate aldolase
Saccharomyces cerevisiae YKL060C   fructose-bisphosphate aldolase FBA1

Essentiality

CaO19.4618 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b2925 Escherichia coli essential goodall
YKL060C Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

Compound Source Reference
ChEMBL23 References
ChEMBL23 References
ChEMBL23 References
ChEMBL23 References
ChEMBL23 References
ChEMBL23 References

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Escherichia coli fructose-bisphosphate aldolase, class II Compounds References
Yersinia pestis Fructose-bisphosphate aldolase class II Compounds References
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) Fructose-bisphosphate aldolase 307 aa 25.8% 330 aa Compounds References
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase 323 aa 22.6% 358 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

  • ChEMBL
  • Inhibition of Candida albicans zinc dependent class 2 Fba

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier CaO19.4618 (Candida albicans), fructose-bisphosphate aldolase
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