Detailed view for CaO19.854

Basic information

TDR Targets ID: 655736
Candida albicans, one of two potential aminotransferase genes
Source Database / ID:  KEGG  

pI: 6.1184 | Length (AA): 434 | MW (Da): 48614 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00202   Aminotransferase class-III

Gene Ontology

Mouse over links to read term descriptions.
GO:0030170   pyridoxal phosphate binding  
GO:0008483   transaminase activity  
GO:0003867   4-aminobutyrate transaminase activity  
GO:0003824   catalytic activity  
GO:0009448   gamma-aminobutyric acid metabolic process  

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129508)

Species Accession Gene Product
Brugia malayi Bm1_27120   4-aminobutyrate aminotransferase, mitochondrial precursor
Candida albicans CaO19.854   one of two potential aminotransferase genes
Candida albicans CaO19.8474   one of two potential aminotransferase genes
Candida albicans CaO19.8421   one of two potential aminotransferase genes similar to S. cerevisiae UGA1 (YGR019W) gamma-aminobutyrate (GABA) transaminase
Caenorhabditis elegans CELE_K04D7.3   Protein GTA-1
Dictyostelium discoideum DDB_G0268104   4-aminobutyrate transaminase
Drosophila melanogaster Dmel_CG7433   CG7433 gene product from transcript CG7433-RC
Homo sapiens ENSG00000183044   4-aminobutyrate aminotransferase
Mus musculus ENSMUSG00000057880   4-aminobutyrate aminotransferase
Mycobacterium tuberculosis Rv3290c   Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase)
Mycobacterium ulcerans MUL_2644   L-lysine aminotransferase
Saccharomyces cerevisiae YGR019W   4-aminobutyrate transaminase
Schmidtea mediterranea mk4.025258.00   Probable 4-aminobutyrate aminotransferase, mitochondrial
Schmidtea mediterranea mk4.026093.01   Probable 4-aminobutyrate aminotransferase, mitochondrial
Schmidtea mediterranea mk4.026257.00  

Essentiality

CaO19.854 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu3349 Mycobacterium tuberculosis non-essential nmpdr
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Sus scrofa Gamma-amino-N-butyrate transaminase Compounds References
Homo sapiens 4-aminobutyrate aminotransferase Compounds References
Rattus norvegicus Gamma-amino-N-butyrate transaminase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier CaO19.854 (Candida albicans), one of two potential aminotransferase genes
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