Detailed view for CaO19.13494

Basic information

TDR Targets ID: 655848
Candida albicans, heme oxygenase induced when hemin is sole source of iron
Source Database / ID:  KEGG  

pI: 7.9091 | Length (AA): 291 | MW (Da): 33972 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 2

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01126   Heme oxygenase

Gene Ontology

Mouse over links to read term descriptions.
GO:0006788   heme oxidation  
GO:0004392   heme oxygenase (decyclizing) activity  
GO:0055114   oxidation reduction  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130942)

Species Accession Gene Product
Candida albicans CaO19.6073   heme oxygenase induced when hemin is sole source of iron
Candida albicans CaO19.13494   heme oxygenase induced when hemin is sole source of iron
Drosophila melanogaster Dmel_CG14716   Heme oxygenase
Homo sapiens ENSG00000103415   heme oxygenase (decycling) 2
Mus musculus ENSMUSG00000004070   heme oxygenase (decycling) 2
Saccharomyces cerevisiae YLR205C   Hmx1p

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Rattus norvegicus Heme oxygenase 2 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Heme oxygenase 1 289 aa 24.6% 232 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier CaO19.13494 (Candida albicans), heme oxygenase induced when hemin is sole source of iron
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