Detailed view for CaO19.3545

Basic information

TDR Targets ID: 655926
Candida albicans, potential protein kinase similar to A.nidulans gene (sepH) required for septation in cytokinesis
Source Database / ID:  KEGG  

pI: 7.0747 | Length (AA): 1126 | MW (Da): 128071 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0005488   binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

Cell cycle - yeast (KEGG)
Meiosis - yeast (KEGG)

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
199 474 2xik (A) 5 283 42.00 0 1 0.743515 -0.47
394 1126 2x19 (B) 200 932 11.00 0 1 0.688877 0.2
845 1016 4d4e (A) 13 186 20.00 0.011 1 0.438853 -1.37

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131527)

Species Accession Gene Product
Arabidopsis thaliana AT3G13530   MAP3K epsilon protein kinase 1
Arabidopsis thaliana AT3G07980   mitogen-activated protein kinase kinase kinase 6
Candida albicans CaO19.3545   potential protein kinase similar to A.nidulans gene (sepH) required for septation in cytokinesis
Candida albicans CaO19.11029   MAPKKK essential for late nuclear division
Dictyostelium discoideum DDB_G0276465   armadillo repeat-containing protein
Entamoeba histolytica EHI_063010   serine/threonine protein kinase, putative
Entamoeba histolytica EHI_009590   serine/threonine protein kinase, putative
Giardia lamblia GL50803_16834   Kinase, STE Dicty2
Oryza sativa 4337283   Os04g0660500
Schmidtea mediterranea mk4.003900.04   Casein kinase II subunit beta
Schmidtea mediterranea mk4.020131.00  
Schmidtea mediterranea mk4.000517.00   Mitogen-activated protein kinase kinase kinase 19
Trichomonas vaginalis TVAG_091160   STE family protein kinase
Trichomonas vaginalis TVAG_038280   STE family protein kinase
Trichomonas vaginalis TVAG_441070   STE family protein kinase

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 25.7% 342 aa Compounds References
Sus scrofa Casein kinase I isoform alpha 125 aa 26.2% 107 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 28.6% 280 aa Compounds References
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 32.9% 152 aa Compounds References
Bos taurus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 26.0% 342 aa Compounds References
Xenopus laevis Aurora kinase B-A 361 aa 25.0% 320 aa Compounds References
Patiria pectinifera Cdc2 300 aa 29.0% 279 aa Compounds References
Oryctolagus cuniculus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 26.0% 342 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 30.5% 285 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier CaO19.3545 (Candida albicans), potential protein kinase similar to A.nidulans gene (sepH) required for septation in cytokinesis
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