Detailed view for CaO19.4620

Basic information

TDR Targets ID: 656025
Candida albicans, protein trans. across mito. Intermembrane space
Source Database / ID:  KEGG  

pI: 8.1154 | Length (AA): 109 | MW (Da): 12424 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02953   Tim10/DDP family zinc finger

Gene Ontology

Mouse over links to read term descriptions.
GO:0042721   mitochondrial inner membrane protein insertion complex  
GO:0045039   protein import into mitochondrial inner membrane  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128839)

Species Accession Gene Product
Arabidopsis thaliana AT2G29530   mitochondrial import inner membrane translocase subunit Tim10
Babesia bovis BBOV_IV008900   mitochondrial transport complex Tim10, putative
Brugia malayi Bm1_18555   Mitochondrial import inner membrane translocase subunit TIM10
Candida albicans CaO19.12090   protein trans. across mito. Intermembrane space
Candida albicans CaO19.4620   protein trans. across mito. Intermembrane space
Caenorhabditis elegans CELE_Y66D12A.22   Protein TIN-10
Dictyostelium discoideum DDB_G0284911   mitochondrial import inner membrane translocase subunit 10
Drosophila melanogaster Dmel_CG9878   Translocase of inner membrane 10
Echinococcus granulosus EgrG_000524500   expressed protein
Echinococcus multilocularis EmuJ_000524500   expressed protein
Homo sapiens ENSG00000134809   translocase of inner mitochondrial membrane 10 homolog (yeast)
Loa Loa (eye worm) LOAG_11210   transport to inner mitochondrial membrane family member
Mus musculus ENSMUSG00000027076   translocase of inner mitochondrial membrane 10
Neospora caninum NCLIV_026310   mitochondrial import inner membrane translocase subunit tim10, putative
Neospora caninum NCLIV_052310   Tim10/DDP family zinc finger containing protein, putative
Oryza sativa 4334631   Os03g0825400
Oryza sativa 4342818   Os07g0243100
Plasmodium berghei PBANKA_0607100   mitochondrial import inner membrane translocase subunit TIM10, putative
Plasmodium falciparum PF3D7_1208600   mitochondrial import inner membrane translocase subunit TIM10, putative
Plasmodium knowlesi PKNH_1308500   mitochondrial import inner membrane translocase subunit TIM10, putative
Plasmodium vivax PVX_084462   mitochondrial import inner membrane translocase subunit TIM10, putative
Plasmodium yoelii PY06161   small zinc finger-like protein-related
Saccharomyces cerevisiae YBR091C   Tim12p
Saccharomyces cerevisiae YHR005C-A   protein transporter TIM10
Schistosoma japonicum Sjp_0036650   Mitochondrial import inner membrane translocase subunit Tim10, putative
Schistosoma mansoni Smp_016130   mitochondrial import inner membrane translocase subunit tim10
Toxoplasma gondii TGME49_260850   mitochondrial import inner membrane translocase subunit TIM10, putative
Toxoplasma gondii TGME49_215390   TIM10 family protein, putative
Theileria parva TP01_0885   mitochondrial import inner membrane translocase subunit tim10, putative

Essentiality

CaO19.4620 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y66D12A.22 Caenorhabditis elegans embryonic lethal wormbase
YHR005C-A Saccharomyces cerevisiae inviable yeastgenome
YBR091C Saccharomyces cerevisiae inviable yeastgenome
PBANKA_0607100 Plasmodium berghei Essential plasmo
TGME49_260850 Toxoplasma gondii Essentiality uncertain sidik
TGME49_215390 Toxoplasma gondii Essentiality uncertain sidik
TGME49_260850 Toxoplasma gondii Probably non-essential sidik
TGME49_215390 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Saccharomyces cerevisiae protein transporter TIM10 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier CaO19.4620 (Candida albicans), protein trans. across mito. Intermembrane space
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