Detailed view for CaO19.11485

Basic information

TDR Targets ID: 656311
Candida albicans, kinase involved in DNA repair
Source Database / ID:  KEGG  

pI: 6.6586 | Length (AA): 414 | MW (Da): 47316 | Paralog Number: 3

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

Cell cycle - yeast (KEGG)

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128695)

Species Accession Gene Product
Candida albicans CaO19.4002   kinase involved in DNA repair
Candida albicans CaO19.11485   kinase involved in DNA repair
Candida albicans CaO19.14198   protein kinase
Candida albicans CaO19.6936   protein kinase
Caenorhabditis elegans CELE_T08D2.7   Protein T08D2.7
Caenorhabditis elegans CELE_Y60A3A.12   Protein CHK-2
Dictyostelium discoideum DDB_G0293656   FHA domain-containing protein
Dictyostelium discoideum DDB_G0280321   FHA domain-containing protein
Dictyostelium discoideum DDB_G0281567   FHA domain-containing protein
Dictyostelium discoideum DDB_G0285963   FHA domain-containing protein
Drosophila melanogaster Dmel_CG10895   loki
Echinococcus granulosus EgrG_000772000   serine:threonine protein kinase Chk2
Echinococcus granulosus EgrG_000826300   calcium:calmodulin dependent protein kinase I
Entamoeba histolytica EHI_011510   protein kinase, putative
Entamoeba histolytica EHI_014100   protein kinase, putative
Echinococcus multilocularis EmuJ_000772000   serine:threonine protein kinase Chk2
Echinococcus multilocularis EmuJ_000826300   calcium:calmodulin dependent protein kinase I
Homo sapiens ENSG00000183765   checkpoint kinase 2
Mus musculus ENSMUSG00000029521   checkpoint kinase 2
Saccharomyces cerevisiae YPL153C   Rad53p
Saccharomyces cerevisiae YDL101C   Dun1p
Schistosoma japonicum Sjp_0004230   ko:K06641 serine/threonine-protein kinase Chk2, putative
Schistosoma mansoni Smp_171370   serine/threonine protein kinase
Schmidtea mediterranea mk4.000295.07  
Schmidtea mediterranea mk4.000295.08   Serine/threonine-protein kinase Chk2

Essentiality

CaO19.11485 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y60A3A.12 Caenorhabditis elegans embryonic lethal wormbase
YPL153C Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens checkpoint kinase 2 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Xenopus laevis Aurora kinase B-A 361 aa 29.1% 313 aa Compounds References
Rattus norvegicus MAP kinase p38 alpha 360 aa 27.2% 320 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 26.6% 320 aa Compounds References
Xenopus laevis Aurora kinase B-B 368 aa 29.3% 307 aa Compounds References
Oryctolagus cuniculus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 31.3% 294 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 27.6% 322 aa Compounds References
Patiria pectinifera Cdc2 300 aa 25.7% 327 aa Compounds References
Rattus norvegicus Mitogen-activated protein kinase 1 358 aa 25.5% 318 aa Compounds References
Schizosaccharomyces pombe 972h- Casein kinase II subunit alpha 332 aa 21.4% 332 aa Compounds References
Bos taurus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 31.3% 300 aa Compounds References
Rattus norvegicus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 31.3% 300 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 23.8% 320 aa Compounds References
Rattus norvegicus Mitogen-activated protein kinase 8 411 aa 26.0% 339 aa Compounds References
Rattus norvegicus Serine/threonine-protein kinase pim-3 326 aa 25.4% 319 aa Compounds References
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 30.1% 163 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier CaO19.11485 (Candida albicans), kinase involved in DNA repair
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