Detailed view for CaO19.992

Basic information

TDR Targets ID: 656966
Candida albicans, leukotriene A4 hydrolase/leucyl aminopeptidase
Source Database / ID:  KEGG  

pI: 5.0093 | Length (AA): 623 | MW (Da): 71436 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01433   Peptidase family M1 domain
PF09127   Leukotriene A4 hydrolase, C-terminal

Gene Ontology

Mouse over links to read term descriptions.
GO:0004463   leukotriene-A4 hydrolase activity  
GO:0008270   zinc ion binding  
GO:0008237   metallopeptidase activity  
GO:0005488   binding  
GO:0006508   proteolysis  

Metabolic Pathways

Arachidonic acid metabolism (KEGG)
Global map (KEGG)

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129538)

Species Accession Gene Product
Arabidopsis thaliana AT5G13520   peptidase M1 family protein
Candida albicans CaO19.992   leukotriene A4 hydrolase/leucyl aminopeptidase
Candida albicans CaO19.8607   leukotriene A4 hydrolase/leucyl aminopeptidase
Caenorhabditis elegans CELE_ZC416.6   Protein ZC416.6
Caenorhabditis elegans CELE_C42C1.11   Protein C42C1.11, isoform B
Dictyostelium discoideum DDB_G0269148   leukotriene A4 hydrolase
Drosophila melanogaster Dmel_CG10602   CG10602 gene product from transcript CG10602-RE
Echinococcus granulosus EgrG_000972400   leukotriene A 4 hydrolase
Echinococcus multilocularis EmuJ_000972400   leukotriene A 4 hydrolase
Homo sapiens ENSG00000111144   leukotriene A4 hydrolase
Loa Loa (eye worm) LOAG_03827   leukotriene A4 hydrolase
Mus musculus ENSMUSG00000015889   leukotriene A4 hydrolase
Oryza sativa 4334583   Os03g0819100
Saccharomyces cerevisiae YNL045W   Lap2p
Schistosoma japonicum Sjp_0022850   ko:K01254 leukotriene-A4 hydrolase [EC3.3.2.6], putative
Schistosoma mansoni Smp_007550   leukotriene A4 hydrolase (M01 family)
Schmidtea mediterranea mk4.000242.04   Leukotriene A-4 hydrolase
Schmidtea mediterranea mk4.022487.00  
Schmidtea mediterranea mk4.019620.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mus musculus leukotriene A4 hydrolase Compounds References
Homo sapiens leukotriene A4 hydrolase Compounds References
Cavia porcellus Leukotriene A-4 hydrolase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier CaO19.992 (Candida albicans), leukotriene A4 hydrolase/leucyl aminopeptidase
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