Detailed view for PF3D7_0828400

Basic information

TDR Targets ID: 657
Plasmodium falciparum, mitochondrial inner membrane protein OXA1, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 9.4742 | Length (AA): 589 | MW (Da): 69693 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 4

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02096   60Kd inner membrane protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0032977   membrane insertase activity  
GO:0016021   integral to membrane  
GO:0051205   protein insertion into membrane  

Metabolic Pathways

Protein export (KEGG)

Structural information

Modbase 3D models:

There are 19 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
464 1873 4rh7 (A) 1256 2640 10.00 0 0.76 -0.0150054 1.83
719 1913 4un4 (B) 83 1317 15.00 0.0088 0.96 0.460017 1.8
977 1160 4jr7 (A) 6 213 28.00 0.66 0.21 -0.089305 2.06
1012 1197 4uos (A) 2 184 19.00 0.0028 0.63 0.448697 -1.56
1866 2113 4tql (A) 9 235 24.00 0.000087 0.57 0.316863 -0.63
1900 2113 1kkh (A) 48 277 28.00 0.69 0.09 0.161227 0.67
1974 2166 4uos (A) 1 184 20.00 0.018 0.08 0.348055 -1.48
31 280 3ffz (A) 308 541 31.00 0.017 0.25 0.397448 1.85
173 317 2aqw (A) 8 162 30.00 0.047 0.15 0.35718 -0.23
301 545 3wo7 (A) 42 261 29.00 0.0000000000055 0.62 0.341959 1.49
494 1311 3zuq (A) 10 892 18.00 0.029 0.84 0.226203 1.5
1015 1198 4uos (A) 2 183 17.00 0.014 0.63 0.395546 -1.43
1284 1373 2lkl (A) 6 81 34.00 0.29 0.52 0.199722 -0.16
1766 1947 4tql (A) 28 189 28.00 0.18 0.19 0.163145 0.49
1870 2117 4tql (A) 9 235 24.00 0.00088 0.63 0.287561 -0.49
1990 2170 4uos (A) 2 184 19.00 0.084 0.57 0.379395 -1.67
42 279 3r4s (A) 923 1199 31.00 0.41 0.32 0.314151 1.26
72 317 3jqq (E) 6 309 27.00 0.47 0.73 0.37478 0.8
299 543 3wo7 (A) 42 261 29.00 0.0000000000055 0.62 0.343076 1.49

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile sporozoite, early schizont, early trophozoite, late ring, late schizont, late trophozoite, Sporozoite. PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Oocyst. Otto TD Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, Ring, Female Gametocyte. Otto TD Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile Male Gametocyte. Lasonder E
Show/Hide expression data references
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.

Orthologs

Ortholog group members (OG5_128453)

Species Accession Gene Product
Arabidopsis thaliana AT2G46470   inner membrane OXA1-like protein
Arabidopsis thaliana AT5G62050   mitochondrial inner membrane protein OXA1
Babesia bovis BBOV_IV002440   cytochrome oxidase biogenesis protein 1-1 (OXA1), putative
Brugia malayi Bm1_54550   60Kd inner membrane protein
Brugia malayi Bm1_54555   60Kd inner membrane protein
Candida albicans CaO19_6565   hypothetical protein
Candida albicans CaO19.6565   assembly of cytochrome oxidase, ATP synthase
Candida albicans CaO19.13918   assembly of cytochrome oxidase, ATP synthase
Caenorhabditis elegans CELE_C01A2.3   Protein C01A2.3
Dictyostelium discoideum DDB_G0284883   hypothetical protein
Dictyostelium discoideum DDB_G0281171   hypothetical protein
Drosophila melanogaster Dmel_CG6404   CG6404 gene product from transcript CG6404-RA
Echinococcus granulosus EgrG_000251800   cytochrome oxidase biogenesis protein
Echinococcus multilocularis EmuJ_000251800   cytochrome oxidase biogenesis protein
Homo sapiens ENSG00000155463   oxidase (cytochrome c) assembly 1-like
Leishmania braziliensis LbrM.11.0980   hypothetical protein, conserved
Leishmania donovani LdBPK_111170.1   60Kd inner membrane protein, putative
Leishmania infantum LinJ.11.1170   hypothetical protein, conserved
Leishmania major LmjF.11.1180   hypothetical protein, conserved
Leishmania mexicana LmxM.11.1180   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_04050   60Kd inner membrane protein
Loa Loa (eye worm) LOAG_04051   hypothetical protein
Mus musculus ENSMUSG00000000959   oxidase assembly 1-like
Oryza sativa 4349143   Os10g0521300
Oryza sativa 4331399   Os03g0116000
Onchocerca volvulus OVOC227   Mitochondrial inner membrane protein homolog
Plasmodium berghei PBANKA_0702300   mitochondrial inner membrane protein OXA1, putative
Plasmodium falciparum PF3D7_0828400   mitochondrial inner membrane protein OXA1, putative
Plasmodium knowlesi PKNH_1322500   mitochondrial inner membrane protein OXA1, putative
Plasmodium vivax PVX_088935   mitochondrial inner membrane protein OXA1, putative
Plasmodium yoelii PY05780   hypothetical protein
Saccharomyces cerevisiae YER154W   Oxa1p
Schistosoma japonicum Sjp_0215380   ko:K03217 preprotein translocase YidC subunit, putative
Schistosoma mansoni Smp_161940   cytochrome oxidase biogenesis protein (oxa1 mitochondrial)
Schmidtea mediterranea mk4.005590.01   Mitochondrial inner membrane protein OXA1L
Schmidtea mediterranea mk4.003072.00   Mitochondrial inner membrane protein OXA1L
Schmidtea mediterranea mk4.004522.01   Mitochondrial inner membrane protein OXA1L
Schmidtea mediterranea mk4.004522.02   Mitochondrial inner membrane protein OXA1L
Schmidtea mediterranea mk4.003739.02   Putative cytochrome oxidase biogenesis protein
Schmidtea mediterranea mk4.015153.01   Mitochondrial inner membrane protein OXA1L
Trypanosoma brucei gambiense Tbg972.11.6930   hypothetical protein, conserved
Trypanosoma brucei Tb927.11.6150   60Kd inner membrane protein, putative
Trypanosoma congolense TcIL3000.11.6680   60Kd inner membrane protein, putative
Trypanosoma cruzi TcCLB.508041.50   60Kd inner membrane protein, putative
Trypanosoma cruzi TcCLB.506297.310   60Kd inner membrane protein, putative
Theileria parva TP03_0408   hypothetical protein

Essentiality

PF3D7_0828400 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.02.4020 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.02.4020 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.02.4020 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.02.4020 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_C01A2.3 Caenorhabditis elegans embryonic lethal wormbase
CELE_C01A2.3 Caenorhabditis elegans larval arrest wormbase
CELE_C01A2.3 Caenorhabditis elegans slow growth wormbase
PBANKA_0702300 Plasmodium berghei Essential plasmo
Show/Hide essentiality data references
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.1

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier PF3D7_0828400 (Plasmodium falciparum), mitochondrial inner membrane protein OXA1, putative
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