Detailed view for CaO19.13084

Basic information

TDR Targets ID: 657206
Candida albicans, Phosphoribosyl-AMP cyclohydrolase
Source Database / ID:  KEGG  

pI: 5.109 | Length (AA): 838 | MW (Da): 91926 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00815   Histidinol dehydrogenase
PF01502   Phosphoribosyl-AMP cyclohydrolase
PF01503   Phosphoribosyl-ATP pyrophosphohydrolase

Gene Ontology

Mouse over links to read term descriptions.
GO:0051287   NAD binding  
GO:0016491   oxidoreductase activity  
GO:0008270   zinc ion binding  
GO:0004636   phosphoribosyl-ATP diphosphatase activity  
GO:0004635   phosphoribosyl-AMP cyclohydrolase activity  
GO:0004399   histidinol dehydrogenase activity  
GO:0055114   oxidation reduction  
GO:0008152   metabolic process  
GO:0000105   histidine biosynthetic process  

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129099)

Species Accession Gene Product
Arabidopsis thaliana AT5G63890   Histidinol dehydrogenase
Candida albicans CaO19.5639   Phosphoribosyl-AMP cyclohydrolase
Candida albicans CaO19.13084   Phosphoribosyl-AMP cyclohydrolase
Escherichia coli b2020   bifunctional histidinal dehydrogenase/histidinol dehydrogenase
Mycobacterium leprae ML1257   Probable histidinol dehydrogenase HisD (HDH)
Mycobacterium tuberculosis Rv1599   Probable histidinol dehydrogenase HisD (HDH)
Mycobacterium ulcerans MUL_1572   histidinol dehydrogenase
Oryza sativa 4324282   Os01g0232700
Saccharomyces cerevisiae YCL030C   trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase

Essentiality

CaO19.13084 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b2020 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Brassica oleracea var. capitata Histidinol dehydrogenase Compounds References
Brucella suis biovar 1 (strain 1330) Histidinol dehydrogenase Compounds References
Escherichia coli bifunctional histidinal dehydrogenase/histidinol dehydrogenase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier CaO19.13084 (Candida albicans), Phosphoribosyl-AMP cyclohydrolase
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