Detailed view for CaO19.1847

Basic information

TDR Targets ID: 657675
Candida albicans, putative indole-3-pyruvate decarboxylase
Source Database / ID:  KEGG  

pI: 6.3456 | Length (AA): 629 | MW (Da): 70812 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02775   Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02776   Thiamine pyrophosphate enzyme, N-terminal TPP binding domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0016831   carboxy-lyase activity  
GO:0003824   catalytic activity  
GO:0030976   thiamin pyrophosphate binding  

Metabolic Pathways

Phenylalanine metabolism (KEGG)
Global map (KEGG)

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_156992)

Species Accession Gene Product
Candida albicans CaO19.1847   putative indole-3-pyruvate decarboxylase
Candida albicans CaO19.9405   putative indole-3-pyruvate decarboxylase
Saccharomyces cerevisiae YDR380W   phenylpyruvate decarboxylase ARO10

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Raphanus raphanistrum Acetolactate synthase 604 aa 22.3% 529 aa Compounds References
Bromus tectorum Acetolactate synthase 583 aa 21.9% 516 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier CaO19.1847 (Candida albicans), putative indole-3-pyruvate decarboxylase
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