Detailed view for CaO19.10414

Basic information

TDR Targets ID: 658395
Candida albicans, sorbose utilization/short-chain alcohol dehydrogenase
Source Database / ID:  KEGG  

pI: 4.914 | Length (AA): 281 | MW (Da): 30038 | Paralog Number: 3

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13561   Enoyl-(Acyl carrier protein) reductase

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131966)

Species Accession Gene Product
Arabidopsis thaliana AT2G29330   tropinone reductase
Arabidopsis thaliana AT1G07450   NAD(P)-binding Rossmann-fold superfamily protein
Arabidopsis thaliana AT2G29310   tropinone reductase-like protein
Arabidopsis thaliana AT2G29300   tropinone reductase-like protein
Arabidopsis thaliana AT1G07440   NAD(P)-binding Rossmann-fold superfamily protein
Arabidopsis thaliana AT2G30670   NAD(P)-binding Rossmann-fold superfamily protein
Arabidopsis thaliana AT2G29340   tropinone reductase-like protein
Arabidopsis thaliana AT2G29320   tropinone reductase-like protein
Candida albicans CaO19.10415   similar to Sou1p but not required for sorbose utilization
Candida albicans CaO19.2897   similar to SOU1 but not required for sorbose utilization
Candida albicans CaO19.2896   sorbose utilization/short-chain alcohol dehydrogenase
Candida albicans CaO19.10414   sorbose utilization/short-chain alcohol dehydrogenase
Mycobacterium tuberculosis Rv1928c   Probable short-chain type dehydrogenase/reductase
Trichomonas vaginalis TVAG_308120   short-chain dehydrogenase, putative

Essentiality

CaO19.10414 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu1959 Mycobacterium tuberculosis non-essential nmpdr
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4) Enoyl-[acyl-carrier-protein] reductase [NADH] 260 aa 23.5% 268 aa Compounds References
Cochliobolus lunatus 17-beta-hydroxysteroid-dehydrogenase 270 aa 26.0% 258 aa Compounds References
Staphylococcus aureus Enoyl-[acyl-carrier-protein] reductase [NADPH] 256 aa 26.1% 261 aa Compounds References
Staphylococcus aureus subsp. aureus MRSA252 Enoyl-[acyl-carrier-protein] reductase 256 aa 26.1% 261 aa Compounds References
Bacillus subtilis (strain 168) Enoyl-[acyl-carrier-protein] reductase [NADH] 258 aa 25.0% 260 aa Compounds References
Staphylococcus aureus (strain NCTC 8325) Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI 256 aa 25.7% 261 aa Compounds References
Trypanosoma brucei pteridine reductase 1 268 aa 29.7% 269 aa Compounds References
Staphylococcus aureus Enoyl-ACP reductase 243 aa 27.0% 241 aa Compounds References
Macaca mulatta Hydroxysteroid 11-beta dehydrogenase 1 140 aa 23.6% 144 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier CaO19.10414 (Candida albicans), sorbose utilization/short-chain alcohol dehydrogenase
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