Detailed view for PF3D7_0802600

Basic information

TDR Targets ID: 669
Plasmodium falciparum, adenylyl cyclase beta
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 7.5704 | Length (AA): 2279 | MW (Da): 269541 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00211   Adenylate and Guanylate cyclase catalytic domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0035556   GO:intracellular signal transduction  

GO:0016849   phosphorus-oxygen lyase activity  
GO:0009190   cyclic nucleotide biosynthetic process  
GO:0007242   intracellular signaling cascade  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 19 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
530 778 1y10 (A) 146 374 13.00 0 1 -0.03 -0.24
606 773 1wc3 (A) 1006 1190 26.00 0 1 0.37 -1.17
121 335 4tql (A) 21 238 14.00 0.051 0.17 0.18044 -0.42
239 925 3s5h (A) 266 1098 24.00 0.046 1 0.238148 1.41
364 500 4wik (A) 448 595 21.00 0.29 0.61 0.307214 -1.29
427 517 4wij (A) 498 588 30.00 0.074 0.04 0.78763 -4.76
742 1035 4wat (A) 193 493 29.00 0.038 0.04 0.118704 1.22
749 919 4ar9 (A) 559 718 33.00 0.21 0.37 0.161733 1.38
1252 1362 1yo8 (A) 827 961 38.00 0.0068 0.07 0.102406 0.91
1540 1794 4hte (A) 304 578 25.00 0.057 1 0.150591 0.69
1770 2037 2y8d (A) 2327 2625 19.00 0.26 0.13 0.182695 -0.35
1924 2236 4k1p (C) 44 353 13.00 0.94 0.25 0.250441 -0.61
388 536 4tql (A) 27 185 24.00 0.59 0.12 0.42077 -1.95
485 760 4clf (A) 179 468 24.00 0 1 0.33944 0.17
583 760 3r5g (A) 224 414 25.00 0 1 0.331787 -0.69
1228 1328 1yo8 (A) 827 945 39.00 0.5 0.06 0.0423889 0.96
1439 2200 5dzt (A) 16 954 15.00 0.00085 0.7 0.290921 0.92
1677 1951 4o87 (A) 17 311 28.00 1 0.15 0.105894 0.89
1895 2196 4hte (A) 284 591 16.00 0.042 0.02 0.197021 -0.07

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile gametocyte, merozoite, sporozoite, early schizont, late ring, late schizont, late trophozoite. PlasmoDB
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, early ring, early trophozoite. Otto TD PlasmoDB
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, Ring, Sporozoite. Otto TD Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, Oocyst, Female Gametocyte, Male Gametocyte. Otto TD Zanghi G Lasonder E
Show/Hide expression data references
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.

Orthologs

Ortholog group members (OG5_140107)

Species Accession Gene Product
Babesia bovis BBOV_IV007360   conserved hypothetical protein
Cryptosporidium hominis Chro.40352   SgcA
Cryptosporidium parvum cgd4_3100   conserved hypothetical protein
Neospora caninum NCLIV_035920   Adenylate/guanylate cyclase with GAF sensor and FHA domain, related
Plasmodium berghei PBANKA_1227600   adenylyl cyclase beta, putative
Plasmodium falciparum PF3D7_0802600   adenylyl cyclase beta
Plasmodium knowlesi PKNH_0116300   adenylyl cyclase beta, putative
Plasmodium vivax PVX_093610   adenylyl cyclase beta, putative
Plasmodium yoelii PY07180   Dictyostelium discoideum SgcA
Toxoplasma gondii TGME49_270865   adenylate cyclase, putative
Theileria parva TP03_0241   hypothetical protein

Essentiality

PF3D7_0802600 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_1227600 Plasmodium berghei Essential plasmo
TGME49_270865 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier PF3D7_0802600 (Plasmodium falciparum), adenylyl cyclase beta
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