Detailed view for Rv2746c

Basic information

TDR Targets ID: 6775
Mycobacterium tuberculosis, Probable PGP synthase PgsA3 (CDP-diacylglycerol--glycerol-3-phosphate 3- phosphatidyltransferase) (phosphatidylglycerophosphate
Source Database / ID:  Tuberculist 

pI: 11.0423 | Length (AA): 209 | MW (Da): 22136 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 4

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01066   CDP-alcohol phosphatidyltransferase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016780   phosphotransferase activity, for other substituted phosphate groups  
GO:0016021   integral to membrane  
GO:0016020   membrane  
GO:0008444   CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity  
GO:0008654   phospholipid biosynthetic process  

Metabolic Pathways

Glycerophospholipid metabolism (KEGG)
Global map (KEGG)

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
80 164 3beh (A) 126 224 39.00 0.45 0.15 0.557299 0.87

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Dormant phase. hasan
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile Dormant phase. murphy
Show/Hide expression data references
  • hasan Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis.
  • murphy Identification of gene targets against dormant phase Mycobacterium tuberculosis infections.

Orthologs

Ortholog group members (OG5_127373)

Species Accession Gene Product
Arabidopsis thaliana AT2G39290   phosphatidylglycerolphosphate synthase 1
Arabidopsis thaliana AT3G55030   phosphatidylglycerolphosphate synthase 2
Arabidopsis thaliana AT4G04870   cardiolipin synthase
Brugia malayi Bm1_51600   Protein C20orf155 homolog
Candida albicans CaO19.6100   cardiolipin synthase
Candida albicans CaO19.13519   cardiolipin synthase
Caenorhabditis elegans CELE_F23H11.9   Protein CRLS-1, isoform B
Chlamydia trachomatis CT_496   CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
Chlamydia trachomatis CT_797   CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
Drosophila melanogaster Dmel_CG4774   cardiolipin synthase
Escherichia coli b1912   phosphatidylglycerophosphate synthetase
Echinococcus granulosus EgrG_000435830   Cardiolipin synthase
Entamoeba histolytica EHI_035400   hypothetical protein
Giardia lamblia GL50803_7259   CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
Homo sapiens ENSG00000088766   cardiolipin synthase 1
Loa Loa (eye worm) LOAG_15474   hypothetical protein
Loa Loa (eye worm) LOAG_04801   hypothetical protein
Mycobacterium leprae ML0979   PROBABLE PGP SYNTHASE PGSA3 (CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3- PHOSPHATIDYLTRANSFERASE) (PHOSPHATIDYLGLYCEROPHOSPHATE
Mycobacterium leprae ML2081c   PROBABLECDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE PGSA2 (PGP SYNTHASE) (PHOSPHATIDYLGLYCEROPHOSPHATE SY
Mus musculus ENSMUSG00000027357   cardiolipin synthase 1
Mycobacterium tuberculosis Rv1822   Probable CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase PgsA2 (PGP synthase) (phosphatidylglycerophosphate s
Mycobacterium tuberculosis Rv2746c   Probable PGP synthase PgsA3 (CDP-diacylglycerol--glycerol-3-phosphate 3- phosphatidyltransferase) (phosphatidylglycerophosphate
Mycobacterium ulcerans MUL_3388   PGP synthase PgsA3
Mycobacterium ulcerans MUL_3041   CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
Neospora caninum NCLIV_008830   CDP-alcohol phosphatidyltransferase domain- containing protein, putative
Oryza sativa 4332460   Os03g0283600
Oryza sativa 4325867   Os01g0789100
Saccharomyces cerevisiae YDL142C   cardiolipin synthase
Schistosoma japonicum Sjp_0307920   expressed protein
Schistosoma mansoni Smp_033210   hypothetical protein
Schmidtea mediterranea mk4.057167.01  
Schmidtea mediterranea mk4.002287.03   Cardiolipin synthase
Schmidtea mediterranea mk4.002287.02   Probable cardiolipin synthase 1
Toxoplasma gondii TGME49_254540   CDP-alcohol phosphatidyltransferase superfamily protein
Treponema pallidum TP0256   CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
Treponema pallidum TP0730   hypothetical protein
Trichomonas vaginalis TVAG_010140   cdp-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, putative
Trichomonas vaginalis TVAG_280790   cdp-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, putative
Trichomonas vaginalis TVAG_093980   cdp-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, putative
Wolbachia endosymbiont of Brugia malayi Wbm0673   phosphatidylglycerophosphate synthase

Essentiality

Rv2746c has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
mtu2793 this record Mycobacterium tuberculosis essential nmpdr
b1912 Escherichia coli essential goodall
TGME49_254540 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

1 literature reference was collected for this gene.

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Gene identifier Rv2746c (Mycobacterium tuberculosis), Probable PGP synthase PgsA3 (CDP-diacylglycerol--glycerol-3-phosphate 3- phosphatidyltransferase) (phosphatidylglycerophosphate
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