Detailed view for Rv0436c

Basic information

TDR Targets ID: 6939
Mycobacterium tuberculosis, Probable CDP-diacylglycerol--serine O-phosphatidyltransferase PssA (PS synthase) (phosphatidylserine synthase)
Source Database / ID:  Tuberculist 

pI: 10.7935 | Length (AA): 286 | MW (Da): 31218 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 5

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01066   CDP-alcohol phosphatidyltransferase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016780   phosphotransferase activity, for other substituted phosphate groups  
GO:0016020   membrane  
GO:0003882   CDP-diacylglycerol-serine O-phosphatidyltransferase activity  
GO:0046341   CDP-diacylglycerol metabolic process  
GO:0008654   phospholipid biosynthetic process  

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
40 143 1qq5 (A) 118 209 37.00 0.33 0.34 0.388036 2.23

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Dormant phase. murphy
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Dormant phase. hasan
Show/Hide expression data references
  • murphy Identification of gene targets against dormant phase Mycobacterium tuberculosis infections.
  • hasan Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis.

Orthologs

Ortholog group members (OG5_129764)

Species Accession Gene Product
Candida albicans CaO19.677   phosphotidylcholine synthase
Candida albicans CaO19.8294   phosphotidylcholine synthase
Chlamydia trachomatis CT_826   CDP-diacylglycerol-serine-O-phosphatidyltransferase
Giardia lamblia GL50803_17427   Hypothetical protein
Homo sapiens 100129924   uncharacterized LOC100129924
Mycobacterium leprae ML0310c   Probable CDP-diacylglycerol-serine o-phosphatidyltransferase PssA (Phosphatidylserine synthase) (PS synthase)
Mus musculus ENSMUSG00000028642   RIKEN cDNA 4930538K18 gene
Mycobacterium tuberculosis Rv0436c   Probable CDP-diacylglycerol--serine O-phosphatidyltransferase PssA (PS synthase) (phosphatidylserine synthase)
Mycobacterium ulcerans MUL_1385   CDP-diacylglycerol--serine O-phosphatidyltransferase
Saccharomyces cerevisiae YER026C   CDP-diacylglycerol-serine O-phosphatidyltransferase
Wolbachia endosymbiont of Brugia malayi Wbm0425   phosphatidylserine synthase

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.1

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Rv0436c (Mycobacterium tuberculosis), Probable CDP-diacylglycerol--serine O-phosphatidyltransferase PssA (PS synthase) (phosphatidylserine synthase)
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