pI: 11.3964 |
Length (AA): 249 |
MW (Da): 26888 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 7
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
110 | 234 | 4lds (A) | 14 | 161 | 33.00 | 0.99 | 0.06 | 0.337208 | 1.46 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | Dormant phase. | hasan |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | Dormant phase. | murphy |
murphy | Identification of gene targets against dormant phase Mycobacterium tuberculosis infections. |
hasan | Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis. |
Ortholog group members (OG5_127224)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G07250 | RHOMBOID-like protein 3 |
Arabidopsis thaliana | AT1G63120 | rhomboid -like 2 |
Arabidopsis thaliana | AT2G29050 | protein RHOMBOID-like 1 |
Arabidopsis thaliana | AT1G12750 | RHOMBOID-like protein 6 |
Arabidopsis thaliana | AT3G53780 | RHOMBOID-like protein 4 |
Arabidopsis thaliana | AT1G25290 | RHOMBOID-like protein 10 |
Brugia malayi | Bm1_50620 | Rhomboid family protein |
Candida albicans | CaO19.5234 | similar to N. crassa orf (NCU01305.1) |
Candida albicans | CaO19.12698 | similar to N. crassa orf (NCU01305.1) |
Caenorhabditis elegans | CELE_Y116A8C.16 | Protein ROM-4, isoform D |
Caenorhabditis elegans | CELE_Y116A8C.14 | Protein ROM-3 |
Dictyostelium discoideum | DDB_G0295849 | rhomboid family protein |
Drosophila melanogaster | Dmel_CG33304 | rhomboid-5 |
Echinococcus granulosus | EgrG_001179900 | inactive rhomboid protein 1 |
Entamoeba histolytica | EHI_197460 | peptidase S54 (rhomboid) family protein |
Echinococcus multilocularis | EmuJ_001179900 | inactive rhomboid protein 1 |
Homo sapiens | ENSG00000129667 | rhomboid 5 homolog 2 (Drosophila) |
Homo sapiens | ENSG00000007384 | rhomboid 5 homolog 1 (Drosophila) |
Loa Loa (eye worm) | LOAG_05867 | rhomboid family protein |
Mus musculus | ENSMUSG00000020806 | rhomboid 5 homolog 2 (Drosophila) |
Mus musculus | ENSMUSG00000020282 | rhomboid family 1 (Drosophila) |
Mycobacterium tuberculosis | Rv0110 | Probable conserved integral membrane protein |
Mycobacterium ulcerans | MUL_4822 | serine protease |
Neospora caninum | NCLIV_013010 | Rhomboid family 1 (Predicted), related |
Oryza sativa | 4347244 | Os09g0454100 |
Oryza sativa | 4351216 | Os11g0704800 |
Oryza sativa | 4331402 | Os03g0116400 |
Oryza sativa | 4346228 | Os08g0546700 |
Oryza sativa | 4349148 | Os10g0521900 |
Oryza sativa | 4347634 | Os09g0525900 |
Oryza sativa | 9266563 | Os01g0147300 |
Oryza sativa | 4336706 | Os04g0569300 |
Onchocerca volvulus | OVOC7140 |
|
Plasmodium berghei | PBANKA_0702700 | rhomboid protease ROM3 |
Plasmodium falciparum | PF3D7_0828000 | rhomboid protease ROM3 |
Plasmodium knowlesi | PKNH_1322100 | rhomboid protease ROM3, putative |
Plasmodium vivax | PVX_088955 | rhomboid protease ROM3, putative |
Plasmodium yoelii | PY01364 | Rhomboid family, putative |
Schistosoma japonicum | Sjp_0086430 | IPR002610,Peptidase S54, rhomboid,domain-containing |
Schistosoma japonicum | Sjp_0311210 | IPR002610,Peptidase S54, rhomboid,domain-containing |
Schistosoma mansoni | Smp_008620 | RHBDF1 protein (S54 family) |
Schmidtea mediterranea | mk4.002600.00 | Inactive rhomboid protein 1 |
Schmidtea mediterranea | mk4.001748.02 | Inactive rhomboid protein 1 |
Toxoplasma gondii | TGME49_212910 | rhomboid protease ROM3 |
Trichomonas vaginalis | TVAG_112900 | Clan S-, family S54, Rhomboid-like serine peptidase |
Trichomonas vaginalis | TVAG_282180 | Clan S-, family S54, Rhomboid-like serine peptidase |
Trichomonas vaginalis | TVAG_161010 | Clan S-, family S54, Rhomboid-like serine peptidase |
Trichomonas vaginalis | TVAG_378960 | Clan S-, family S54, Rhomboid-like serine peptidase |
Trichomonas vaginalis | TVAG_233140 | Clan S-, family S54, Rhomboid-like serine peptidase |
Trichomonas vaginalis | TVAG_359500 | Clan S-, family S54, Rhomboid-like serine peptidase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu111 this record | Mycobacterium tuberculosis | non-essential | nmpdr |
PBANKA_0702700 | Plasmodium berghei | Dispensable | plasmo |
TGME49_212910 | Toxoplasma gondii | Probably non-essential | sidik |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.