Detailed view for Rv1461

Basic information

TDR Targets ID: 7948
Mycobacterium tuberculosis, Conserved protein

Source Database / ID:  Tuberculist 

pI: 6.3407 | Length (AA): 846 | MW (Da): 94171 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01458   Uncharacterized protein family (UPF0051)
PF05203  

Gene Ontology

Mouse over links to read term descriptions.
GO:0030908   protein splicing  
GO:0005515   protein binding  
GO:0004519   endonuclease activity  
GO:0016226   iron-sulfur cluster assembly  
GO:0016539   intein-mediated protein splicing  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
252 613 1jva (A) 283 739 19.00 0 1 0.427096 0.33
563 846 5awf (A) 213 495 39.00 0 1 0.797397 -0.28
609 843 1vh4 (A) 186 420 21.00 0 1 0.586478 -0.35

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Dormant phase, Dormant phase. hasan murphy
Show/Hide expression data references
  • hasan Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis.
  • murphy Identification of gene targets against dormant phase Mycobacterium tuberculosis infections.

Orthologs

Ortholog group members (OG5_129985)

Species Accession Gene Product
Arabidopsis thaliana AT5G44316   Stabilizer of iron transporter SufD superfamily protein
Arabidopsis thaliana AT4G04770   ATP binding cassette protein 1
Chlamydia trachomatis CT_684   iron-sulfur assembly protein SufB
Escherichia coli b1683   component of SufBCD Fe-S cluster assembly scaffold
Mycobacterium leprae ML0593   Conserved hypothetical protein
Mycobacterium tuberculosis Rv1461   Conserved protein
Mycobacterium ulcerans MUL_1862   hypothetical protein
Oryza sativa 4327425   Os01g0830000
Plasmodium berghei PBANKA_API00120   FeS cluster assembly protein SufB, putative
Plasmodium falciparum PF3D7_API04700   FeS cluster assembly protein SufB
Plasmodium knowlesi PKNH_API05600   FeS cluster assembly protein SufB, putative
Plasmodium yoelii PY00058   Uncharacterized protein family UPF0051, putative
Schmidtea mediterranea mk4.059263.01  
Treponema pallidum TP0612   hypothetical protein

Essentiality

Rv1461 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
mtu1484 this record Mycobacterium tuberculosis essential nmpdr
b1683 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Rv1461 (Mycobacterium tuberculosis), Conserved protein
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