Detailed view for EHI_011180

Basic information

TDR Targets ID: 797745
Entamoeba histolytica, protein kinase domain containing protein
Source Database / ID:  AmoebaDB  

pI: 6.111 | Length (AA): 561 | MW (Da): 66421 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 529 4oli (A) 584 1166 20.00 0 1 1.00536 0.7
283 535 2y7j (A) 24 292 30.00 0 1 0.70538 -0.42
283 536 2rku (A) 53 307 27.00 0 1 0.724163 -0.29
376 502 5ve6 (A) 1119 1288 38.00 0.092 0.39 0.271081 0.66

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Trophozoite, Rahman HM-1 IMSS Trophozoite. Hon CC
Show/Hide expression data references
  • Hon CC Transcriptomics of virulent and avirulent strains

Orthologs

Ortholog group members (OG5_200592)

Species Accession Gene Product
Entamoeba histolytica EHI_011180   protein kinase domain containing protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Zea mays Casein kinase II alpha 332 aa 22.0% 309 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 27.5% 302 aa Compounds References
Patiria pectinifera Cdc2 300 aa 23.1% 299 aa Compounds References
Sus scrofa Casein kinase I isoform alpha 125 aa 25.8% 128 aa Compounds References
Schizosaccharomyces pombe 972h- Casein kinase II subunit alpha 332 aa 22.2% 306 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 23.6% 305 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 25.6% 305 aa Compounds References
Rattus norvegicus Mitogen-activated protein kinase 1 358 aa 27.2% 302 aa Compounds References
Rattus norvegicus Serine/threonine-protein kinase pim-3 326 aa 22.5% 271 aa Compounds References
Bos taurus Casein kinase I isoform alpha 325 aa 23.4% 291 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0042 0.5 0.5
0.0018 0.5 0.5
0.0059 1 1
0.0069 0.3067 0.5
0.0004 0.5 0.5
0.0091 1 0.5
0.0081 0.5 0.5
0.0063 1 1
0.0033 0.5 0.5
0.0007 0.5 0.5
0.0008 0.5 0.5
0.0011 1 0.5
0.0029 0.5 0.5
0.0092 1 0.5
0.0007 0.5 0.5
0.0023 0.5 0.5
0.0098 0.3242 0.3167
0.0039 0.9485 0.5
0.0059 1 1
0.0062 0.6935 0
0.0066 0.3101 0
0.0027 1 0.5
0.0016 0.5 0.5
0.0067 0.5 0.5
0.0039 0.5 0.5
0.0036 0.5 0.5
0.0061 0.6883 0.6247
0.0026 0.5 0.5
0.0056 1 0.5
0.0088 0.4477 0.5
0.0081 1 0.5
0.0032 0.5 0.5
0.0093 0.8828 0
0.0059 1 1
0.0022 0.5 0.5
0.0063 0.7244 0
0.0064 0.3377 0.8757
0.0033 1 1
0.0016 0.5 0.5
0.0012 0.5 0.5
0.0007 0.5 0.5
0.0037 1 0.5
0.0032 0.5 0.5
0.0039 0.5 0.5
0.0012 0.5 0.5
0.0003 0.5 0.5
0.0012 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier EHI_011180 (Entamoeba histolytica), protein kinase domain containing protein
Title for this comment
Comment