Detailed view for EHI_155520

Basic information

TDR Targets ID: 798013
Entamoeba histolytica, glutamine synthetase, putative
Source Database / ID:  AmoebaDB  

pI: 5.68 | Length (AA): 718 | MW (Da): 81825 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00120   Glutamine synthetase, catalytic domain
PF12437   Glutamine synthetase type III N terminal

Gene Ontology

Mouse over links to read term descriptions.
GO:0004356   glutamate-ammonia ligase activity  
GO:0003824   catalytic activity  
GO:0006807   nitrogen compound metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 716 3o6x (A) 21 728 33.00 0 1 1.22783 0.03
209 404 3ng0 (A) 126 332 33.00 0.000000045 1 0.542481 0.54
510 673 4uos (A) 12 176 16.00 0.1 0.09 0.498812 -1.15

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile Trophozoite. Hon CC
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Rahman HM-1 IMSS Trophozoite. Hon CC
Show/Hide expression data references
  • Hon CC Transcriptomics of virulent and avirulent strains

Orthologs

Ortholog group members (OG5_141430)

Species Accession Gene Product
Dictyostelium discoideum DDB_G0279591   glutamate-ammonia ligase
Entamoeba histolytica EHI_155520   glutamine synthetase, putative
Entamoeba histolytica EHI_095110   glutamine synthetase, putative
Mycobacterium ulcerans MUL_2782   hypothetical protein
Trichomonas vaginalis TVAG_439420   glutamine synthetase-bacteria, putative
Trichomonas vaginalis TVAG_415140   glutamine synthetase, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EHI_155520 (Entamoeba histolytica), glutamine synthetase, putative
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