Detailed view for EHI_127220

Basic information

TDR Targets ID: 798093
Entamoeba histolytica, synapsin, putative
Source Database / ID:  AmoebaDB  

pI: 7.6236 | Length (AA): 314 | MW (Da): 36253 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02078   Synapsin, N-terminal domain
PF02750   Synapsin, ATP binding domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0008021   synaptic vesicle  
GO:0005524   ATP binding  
GO:0007269   neurotransmitter secretion  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
5 311 1i7n (A) 113 418 38.00 0 1 1.45521 -0.49
5 311 2p0a (A) 90 396 39.00 0 1 1.42241 -0.42
8 310 1pk8 (A) 114 416 36.00 0 1 1.41347 -0.4

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile Trophozoite, Rahman HM-1 IMSS Trophozoite. Hon CC
Show/Hide expression data references
  • Hon CC Transcriptomics of virulent and avirulent strains

Orthologs

Ortholog group members (OG5_130090)

Species Accession Gene Product
Brugia malayi Bm1_37085   Synapsin, ATP binding domain containing protein
Caenorhabditis elegans CELE_Y38C1BA.2   Protein SNN-1, isoform A
Drosophila melanogaster Dmel_CG3985   Synapsin
Echinococcus granulosus EgrG_001177700   synapsin
Entamoeba histolytica EHI_127220   synapsin, putative
Echinococcus multilocularis EmuJ_001177700   synapsin
Homo sapiens ENSG00000157152   synapsin II
Homo sapiens ENSG00000008056   synapsin I
Homo sapiens ENSG00000185666   synapsin III
Loa Loa (eye worm) LOAG_06266   hypothetical protein
Loa Loa (eye worm) LOAG_12773   hypothetical protein
Mus musculus ENSMUSG00000009394   synapsin II
Mus musculus ENSMUSG00000059602   synapsin III
Mus musculus ENSMUSG00000037217   synapsin I
Schistosoma japonicum Sjp_0089390   Synapsin [Contains: Synapsin-1, putative
Schistosoma japonicum Sjp_0104030   Synapsin-3, putative
Schistosoma mansoni Smp_126990   synapsin
Schmidtea mediterranea mk4.004263.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Bos taurus Synapsin-1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

No enough druggable targets predicted through repurposing network model to make a plot

Putative Drugs List

Compound Raw Global Species
0.0146 0.5585 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EHI_127220 (Entamoeba histolytica), synapsin, putative
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