Detailed view for EHI_006940

Basic information

TDR Targets ID: 798470
Entamoeba histolytica, hypothetical protein, conserved
Source Database / ID:  AmoebaDB  

pI: 5.3961 | Length (AA): 368 | MW (Da): 41209 | Paralog Number: 4

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 9

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00892   EamA-like transporter family

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  
GO:0016021   integral to membrane  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
256 353 5j4i (A) 320 439 31.00 0 0.1 -0.0400957 2.94

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Trophozoite, Rahman HM-1 IMSS Trophozoite. Hon CC
Show/Hide expression data references
  • Hon CC Transcriptomics of virulent and avirulent strains

Orthologs

Ortholog group members (OG5_127586)

Species Accession Gene Product
Arabidopsis thaliana AT4G18190   purine permease 6
Brugia malayi Bm1_42075   zgc:92765
Candida albicans CaO19.10408   hypothetical protein
Candida albicans CaO19.2890   hypothetical protein
Caenorhabditis elegans CELE_C29H12.2   Protein C29H12.2
Drosophila melanogaster Dmel_CG10007   Transport and Golgi organization 9
Entamoeba histolytica EHI_147870   hypothetical protein, conserved
Entamoeba histolytica EHI_006940   hypothetical protein, conserved
Entamoeba histolytica EHI_131130   hypothetical protein, conserved
Entamoeba histolytica EHI_092680   hypothetical protein, conserved
Entamoeba histolytica EHI_152470   hypothetical protein, conserved
Giardia lamblia GL50803_22291   Hypothetical protein
Giardia lamblia GL50803_9036   Hypothetical protein
Homo sapiens ENSG00000213699   solute carrier family 35, member F6
Leishmania braziliensis LbrM.35.0790   hypothetical protein, conserved
Leishmania donovani LdBPK_360730.1   EamA-like transporter family, putative
Leishmania infantum LinJ.36.0730   hypothetical protein, conserved
Leishmania major LmjF.36.0670   hypothetical protein, conserved
Leishmania mexicana LmxM.36.0670   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_02297   hypothetical protein
Mus musculus ENSMUSG00000029175   solute carrier family 35, member F6
Onchocerca volvulus OVOC10794   Solute carrier family 35 member F6 homolog
Schistosoma japonicum Sjp_0021820   similar to Uncharacterized protein C2orf18 precursor, putative
Schistosoma mansoni Smp_163220   hypothetical protein
Schmidtea mediterranea mk4.015879.01   Solute carrier family 35 member F6
Trichomonas vaginalis TVAG_197230   conserved hypothetical protein
Trichomonas vaginalis TVAG_263910   conserved hypothetical protein
Trichomonas vaginalis TVAG_328950   conserved hypothetical protein
Trichomonas vaginalis TVAG_019740   conserved hypothetical protein
Trichomonas vaginalis TVAG_286280   conserved hypothetical protein
Trichomonas vaginalis TVAG_254470   conserved hypothetical protein
Trichomonas vaginalis TVAG_203880   conserved hypothetical protein
Trichomonas vaginalis TVAG_432780   conserved hypothetical protein
Trichomonas vaginalis TVAG_497440   conserved hypothetical protein
Trichomonas vaginalis TVAG_005580   conserved hypothetical protein
Trichomonas vaginalis TVAG_492760   conserved hypothetical protein

Essentiality

EHI_006940 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C29H12.2 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EHI_006940 (Entamoeba histolytica), hypothetical protein, conserved
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