Detailed view for EHI_061000

Basic information

TDR Targets ID: 798541
Entamoeba histolytica, acetyltransferase, putative
Source Database / ID:  AmoebaDB  

pI: 9.1334 | Length (AA): 181 | MW (Da): 21407 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00583   Acetyltransferase (GNAT) family

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
4 179 4u9v (B) 28 217 24.00 0 1 1.33208 -1.06
22 181 4ua3 (A) 33 201 29.00 0 1 1.15878 -0.61
72 181 1qst (A) 86 203 15.00 0 0.63 0.652535 0.22

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile Rahman HM-1 IMSS Trophozoite. Hon CC
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Trophozoite. Hon CC
Show/Hide expression data references
  • Hon CC Transcriptomics of virulent and avirulent strains

Orthologs

Ortholog group members (OG5_128515)

Species Accession Gene Product
Arabidopsis thaliana AT1G18335   acyl-CoA N-acyltransferases-like protein
Babesia bovis BBOV_III001570   acetyltransferase, GNAT family protein
Brugia malayi Bm1_53215   acetyltransferase, GNAT family protein
Candida albicans CaO19.4664   potential N-acetyl tranferase (GNAT) superfamily protein with weak similarity to S. cerevisiae NAT4 (YMR069W) histone acetyltran
Caenorhabditis elegans CELE_Y38A10A.7   Protein Y38A10A.7
Cryptosporidium hominis Chro.60217   hypothetical protein
Cryptosporidium parvum cgd6_1800   acetyltransferase, GNAT family
Drosophila melanogaster Dmel_CG7593   CG7593 gene product from transcript CG7593-RA
Echinococcus granulosus EgrG_001036500   n alpha acetyltransferase 40 NatD catalytic
Entamoeba histolytica EHI_061000   acetyltransferase, putative
Echinococcus multilocularis EmuJ_001036500   n alpha acetyltransferase 40, NatD catalytic
Homo sapiens ENSG00000110583   N(alpha)-acetyltransferase 40, NatD catalytic subunit
Loa Loa (eye worm) LOAG_06868   hypothetical protein
Mus musculus ENSMUSG00000024764   N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog (S. cerevisiae)
Neospora caninum NCLIV_030730   acetyltransferase domain-containing protein, putative
Oryza sativa 4338664   Os05g0387800
Oryza sativa 4330878   Os02g0772300
Plasmodium berghei PBANKA_1338500   acetyltransferase, GNAT family, putative
Plasmodium falciparum PF3D7_1323300   acetyltransferase, GNAT family, putative
Plasmodium knowlesi PKNH_1205500   acetyltransferase, GNAT family, putative
Plasmodium vivax PVX_116705   N-acetyltransferase, putative
Plasmodium yoelii PY04599   acetyltransferase, GNAT family, putative
Saccharomyces cerevisiae YMR069W   Nat4p
Schistosoma japonicum Sjp_0102940   ko:K00680 N-acetyltransferase [EC:2.3.1.-], putative
Schistosoma mansoni Smp_115340   acetyltransferase (gnat) family containing protein
Toxoplasma gondii TGME49_230060   acetyltransferase, GNAT family protein
Theileria parva TP03_0684   hypothetical protein
Trichomonas vaginalis TVAG_213690   conserved hypothetical protein
Trichomonas vaginalis TVAG_064180   spcc825.04C protein, putative
Trichomonas vaginalis TVAG_275960   conserved hypothetical protein
Trichomonas vaginalis TVAG_319280   conserved hypothetical protein
Trichomonas vaginalis TVAG_083480   conserved hypothetical protein

Essentiality

EHI_061000 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
TGME49_230060 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0004 0.5 0.5
0.0003 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EHI_061000 (Entamoeba histolytica), acetyltransferase, putative
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