Detailed view for EHI_004400

Basic information

TDR Targets ID: 798555
Entamoeba histolytica, hypothetical protein
Source Database / ID:  AmoebaDB  

pI: 7.1338 | Length (AA): 141 | MW (Da): 17009 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00787   PX domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0035091   phosphoinositide binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 139 2csk (A) 3 135 25.00 0 0.99 1.29192 -0.06
8 137 3dyt (A) 248 360 29.00 0 1 0.990486 -0.17
9 135 1o7k (A) 6 122 18.00 0 0.96 1.07021 -0.32
10 132 4oxw (A) 5 109 32.00 0.0000022 1 1.16554 -0.72
11 84 2dyb (B) 19 96 39.00 0.061 0.33 0.599023 1.1

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Trophozoite, Rahman HM-1 IMSS Trophozoite. Hon CC
Show/Hide expression data references
  • Hon CC Transcriptomics of virulent and avirulent strains

Orthologs

Ortholog group members (OG5_129323)

Species Accession Gene Product
Brugia malayi Bm1_26490   Sorting nexin 12
Candida albicans CaO19.12580   potential phosphoinositide-binding protein similar to S. cerevisiae GRD19 (YOR357C) late Golgi protein involved in retrieval of
Candida albicans CaO19.5114   potential phosphoinositide-binding protein similar to S. cerevisiae GRD19 (YOR357C) late Golgi protein involved in retrieval of
Caenorhabditis elegans CELE_W06D4.5   Protein SNX-3
Dictyostelium discoideum DDB_G0276471   hypothetical protein
Drosophila melanogaster Dmel_CG6359   Sorting nexin 3
Echinococcus granulosus EgrG_000922200   sorting nexin
Entamoeba histolytica EHI_004400   hypothetical protein
Echinococcus multilocularis EmuJ_000922200   sorting nexin
Homo sapiens ENSG00000112335   sorting nexin 3
Homo sapiens ENSG00000147164   sorting nexin 12
Loa Loa (eye worm) LOAG_13370   sorting nexin 12
Mus musculus ENSMUSG00000046032   sorting nexin 12
Mus musculus ENSMUSG00000019804   sorting nexin 3
Saccharomyces cerevisiae YOR357C   Snx3p
Schistosoma japonicum Sjp_0218750   Sorting nexin-12, putative
Schistosoma mansoni Smp_091730   sorting nexin
Schmidtea mediterranea mk4.002128.00  
Schmidtea mediterranea mk4.028963.00  
Schmidtea mediterranea mk4.007267.01  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EHI_004400 (Entamoeba histolytica), hypothetical protein
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