Detailed view for EHI_151200

Basic information

TDR Targets ID: 798747
Entamoeba histolytica, hypothetical protein, conserved
Source Database / ID:  AmoebaDB  

pI: 5.0889 | Length (AA): 440 | MW (Da): 51133 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13181   Tetratricopeptide repeat
PF13414   TPR repeat

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
7 399 4j0u (A) 2 432 15.00 0 1 1.01948 0.14
315 376 3sz7 (A) 119 180 34.00 0.047 1 0.702509 -1.34
362 393 2vyi (A) 177 208 38.00 0.047 0.91 0.729827 -2.04

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Rahman HM-1 IMSS Trophozoite. Hon CC
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile Trophozoite. Hon CC
Show/Hide expression data references
  • Hon CC Transcriptomics of virulent and avirulent strains

Orthologs

Ortholog group members (OG5_128428)

Species Accession Gene Product
Arabidopsis thaliana AT5G02590   tetratricopeptide repeat domain-containing protein
Brugia malayi Bm1_21195   jmjC domain containing protein
Candida albicans CaO19.6798   General repressor of transcription
Candida albicans CaO19.14090   General repressor of transcription
Caenorhabditis elegans CELE_D2021.1   Protein UTX-1
Dictyostelium discoideum DDB_G0269194   hypothetical protein
Drosophila melanogaster Dmel_CG5640   CG5640 gene product from transcript CG5640-RB
Echinococcus granulosus EgrG_000194300   lysine specific demethylase 6a
Entamoeba histolytica EHI_151200   hypothetical protein, conserved
Echinococcus multilocularis EmuJ_000194300   lysine specific demethylase 6a
Homo sapiens ENSG00000279947   ubiquitously transcribed tetratricopeptide repeat containing, Y-linked
Homo sapiens ENSG00000132510   lysine (K)-specific demethylase 6B
Homo sapiens ENSG00000147050   lysine (K)-specific demethylase 6A
Loa Loa (eye worm) LOAG_14578   hypothetical protein
Loa Loa (eye worm) LOAG_12392   hypothetical protein
Loa Loa (eye worm) LOAG_07762   hypothetical protein
Mus musculus ENSMUSG00000018476   KDM1 lysine (K)-specific demethylase 6B
Mus musculus ENSMUSG00000068457   ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome
Mus musculus ENSMUSG00000037369   lysine (K)-specific demethylase 6A
Saccharomyces cerevisiae YBR112C   Cyc8p
Schistosoma japonicum Sjp_0071500   hypothetical protein
Schistosoma japonicum Sjp_0071510   Ubiquitously transcribed X chromosome tetratricopeptide repeat protein, putative
Schistosoma mansoni Smp_034000   ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related
Schmidtea mediterranea mk4.001470.01  
Schmidtea mediterranea mk4.001470.00   Utx
Trichomonas vaginalis TVAG_206190   O-linked N-acetylglucosamine transferase, ogt, putative
Trichomonas vaginalis TVAG_024830   O-linked N-acetylglucosamine transferase, ogt, putative
Trichomonas vaginalis TVAG_316100   O-linked N-acetylglucosamine transferase, ogt, putative
Trichomonas vaginalis TVAG_587610   O-linked N-acetylglucosamine transferase, ogt, putative
Trichomonas vaginalis TVAG_243980   O-linked N-acetylglucosamine transferase, ogt, putative
Trichomonas vaginalis TVAG_257630   conserved hypothetical protein
Trichomonas vaginalis TVAG_046440   conserved hypothetical protein
Trichomonas vaginalis TVAG_353370   conserved hypothetical protein
Trichomonas vaginalis TVAG_486820   O-linked N-acetylglucosamine transferase, ogt, putative
Trichomonas vaginalis TVAG_219150   conserved hypothetical protein
Trichomonas vaginalis TVAG_154490   O-linked N-acetylglucosamine transferase, ogt, putative

Essentiality

EHI_151200 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_D2021.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_D2021.1 Caenorhabditis elegans slow growth wormbase
YBR112C Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens lysine (K)-specific demethylase 6B Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EHI_151200 (Entamoeba histolytica), hypothetical protein, conserved
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