Detailed view for EHI_045400

Basic information

TDR Targets ID: 798776
Entamoeba histolytica, Arf GTPase activating protein, putative
Source Database / ID:  AmoebaDB  

pI: 6.7687 | Length (AA): 598 | MW (Da): 69502 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01412   Putative GTPase activating protein for Arf

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  
GO:0005096   GTPase activator activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
28 199 4uos (A) 9 173 16.00 0.0004 0.73 0.582925 -1.49
341 435 3dwd (A) 4 102 42.00 0.0000000037 1 0.636363 -0.23
342 579 2b0o (E) 428 682 30.00 0 1 0.708493 -0.46
455 572 2bkk (B) 44 166 31.00 0.000092 1 0.604824 -0.43

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Rahman HM-1 IMSS Trophozoite. Hon CC
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Trophozoite. Hon CC
Show/Hide expression data references
  • Hon CC Transcriptomics of virulent and avirulent strains

Orthologs

Ortholog group members (OG5_129717)

Species Accession Gene Product
Brugia malayi Bm1_09300   GTP-ase activating protein for Arf containing protein
Drosophila melanogaster Dmel_CG30372   ArfGAP with SH3 domain, ankyrin repeat and PH domain
Echinococcus granulosus EgrG_001104300   arf GAP with SH3 domain ANK repeat and PH
Entamoeba histolytica EHI_045400   Arf GTPase activating protein, putative
Entamoeba histolytica EHI_138360   ARF GTPase activating protein, putative
Echinococcus multilocularis EmuJ_001104300   arf GAP with SH3 domain, ANK repeat and PH
Homo sapiens ENSG00000153317   ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
Homo sapiens ENSG00000088280   ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
Homo sapiens ENSG00000151693   ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
Loa Loa (eye worm) LOAG_08569   GTP-ase activating protein for Arf containing protein
Mus musculus ENSMUSG00000036995   ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
Mus musculus ENSMUSG00000022377   ArfGAP with SH3 domain, ankyrin repeat and PH domain1
Mus musculus ENSMUSG00000052632   ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
Saccharomyces cerevisiae YDR524C   Age1p
Schistosoma mansoni Smp_125430   development and differentiation-enhancing factor ddef
Schmidtea mediterranea mk4.001438.02   Putative development and differentiation-enhancing factor, ddef
Schmidtea mediterranea mk4.001438.01   Putative development and differentiation-enhancing factor, ddef
Schmidtea mediterranea mk4.012933.00   Putative development and differentiation-enhancing factor, ddef

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0036 0.4145 1
0.0036 0.7769 0.7843
0.0034 0.4145 1
0.0033 0.2538 1
0.0036 0.7792 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier EHI_045400 (Entamoeba histolytica), Arf GTPase activating protein, putative
Title for this comment
Comment