Detailed view for EHI_001770

Basic information

TDR Targets ID: 799388
Entamoeba histolytica, sodium/calcium exchanger protein, putative
Source Database / ID:  AmoebaDB  

pI: 5.6058 | Length (AA): 513 | MW (Da): 57026 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 13

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01699   Sodium/calcium exchanger protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0055085   transmembrane transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
63 217 5hya (A) 10 164 29.00 0.0000043 0.09 0.278144 2.05
178 303 3zhe (A) 147 276 13.00 0 0.18 0.381414 -0.56
206 270 4z8n (A) 308 369 6.00 0 0 0.190506 -0.88

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Trophozoite, Rahman HM-1 IMSS Trophozoite. Hon CC
Show/Hide expression data references
  • Hon CC Transcriptomics of virulent and avirulent strains

Orthologs

Ortholog group members (OG5_127811)

Species Accession Gene Product
Arabidopsis thaliana AT5G17860   calcium exchanger 7
Arabidopsis thaliana AT1G54115   cation/calcium exchanger 4
Arabidopsis thaliana AT3G14070   cation/calcium exchanger 3
Arabidopsis thaliana AT1G08960   cation/calcium exchanger 5
Candida albicans CaO19.4981   similar to CaCA sodium/calcium exchanger
Candida albicans CaO19.12448   similar to CaCA sodium/calcium exchanger
Caenorhabditis elegans CELE_C07A9.4   Protein NCX-6
Caenorhabditis elegans CELE_C13D9.7   Protein NCX-8
Caenorhabditis elegans CELE_C13D9.8   Protein NCX-9
Caenorhabditis elegans CELE_Y97E10B.7   Protein NCX-10, isoform B
Caenorhabditis elegans CELE_C07A9.11   Protein NCX-7
Drosophila melanogaster Dmel_CG14744   CG14744 gene product from transcript CG14744-RD
Drosophila melanogaster Dmel_CG12376   CG12376 gene product from transcript CG12376-RA
Drosophila melanogaster Dmel_CG14743   CG14743 gene product from transcript CG14743-RB
Drosophila melanogaster Dmel_CG5348   CG5348 gene product from transcript CG5348-RC
Drosophila melanogaster Dmel_CG13223   CG13223 gene product from transcript CG13223-RA
Entamoeba histolytica EHI_001770   sodium/calcium exchanger protein, putative
Homo sapiens ENSG00000089060   solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
Mus musculus ENSMUSG00000032754   solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
Oryza sativa 4333615   Os03g0656500
Oryza sativa 4348706   Os10g0436900
Oryza sativa 4331825   Os03g0180000
Oryza sativa 4352835   Os12g0624200
Saccharomyces cerevisiae YJR106W   Ecm27p
Saccharomyces cerevisiae YDL206W   hypothetical protein
Schmidtea mediterranea mk4.009662.04   Putative na/ca exchanger
Schmidtea mediterranea mk4.001816.08   Putative na/ca exchanger
Schmidtea mediterranea mk4.009662.00   Putative na/ca exchanger

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EHI_001770 (Entamoeba histolytica), sodium/calcium exchanger protein, putative
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