pI: 9.9769 |
Length (AA): 186 |
MW (Da): 21888 |
Paralog Number:
2
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 0-20% percentile | Trophozoite, Rahman HM-1 IMSS Trophozoite. | Hon CC |
Hon CC | Transcriptomics of virulent and avirulent strains |
Ortholog group members (OG5_128165)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G15750 | alpha-L RNA-binding motif/ribosomal protein S4 family protein |
Babesia bovis | BBOV_IV002230 | U3 small nucleolar ribonucleoprotein protein IMP3-like protein |
Brugia malayi | Bm1_03935 | 40S ribosomal protein S4-like |
Candida albicans | CaO19.7488 | similar to S. cerevisiae IMP3 (YHR148W) component of U3 snoRNP involved in pre-18S rRNA processing |
Caenorhabditis elegans | CELE_C48B6.2 | Protein C48B6.2 |
Cryptosporidium hominis | Chro.70129 | S4 domain |
Cryptosporidium parvum | cgd7_1040 | Imp3p-like 40S ribosomal protein S9. S4 RNA binding domain |
Dictyostelium discoideum | DDB_G0278983 | U3 small nucleolar ribonucleoprotein protein |
Drosophila melanogaster | Dmel_CG4866 | CG4866 gene product from transcript CG4866-RA |
Echinococcus granulosus | EgrG_000214200 | U3 small nucleolar ribonucleoprotein |
Entamoeba histolytica | EHI_146820 | U3 small nucleolar ribonucleoprotein subunit, putative |
Entamoeba histolytica | EHI_184000 | U3 small nucleolar ribonucleoprotein subunit, putative |
Entamoeba histolytica | EHI_035170 | U3 small nucleolar ribonucleoprotein subunit, putative |
Echinococcus multilocularis | EmuJ_000214200 | U3 small nucleolar ribonucleoprotein |
Giardia lamblia | GL50803_11319 | U3 small nucleolar ribonucleoprotein protein IMP3, putative |
Homo sapiens | ENSG00000177971 | IMP3, U3 small nucleolar ribonucleoprotein |
Leishmania braziliensis | LbrM.32.0770 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_320720.1 | hypothetical protein, conserved |
Leishmania infantum | LinJ.32.0720 | hypothetical protein, conserved |
Leishmania major | LmjF.32.0690 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.31.0690 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_05536 | hypothetical protein |
Mus musculus | ENSMUSG00000032288 | IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast) |
Neospora caninum | NCLIV_003710 | U3 small nucleolar ribonucleoprotein protein IMP3, putative |
Oryza sativa | 4337293 | Os04g0662100 |
Plasmodium berghei | PBANKA_1324900 | U3 small nucleolar ribonucleoprotein protein IMP3, putative |
Plasmodium falciparum | PF3D7_1461200 | U3 small nucleolar ribonucleoprotein protein IMP3, putative |
Plasmodium knowlesi | PKNH_1220500 | U3 small nucleolar ribonucleoprotein protein IMP3, putative |
Plasmodium vivax | PVX_117395 | U3 small nucleolar ribonucleoprotein protein IMP3, putative |
Plasmodium yoelii | PY04143 | S4 domain, putative |
Saccharomyces cerevisiae | YHR148W | Imp3p |
Schistosoma japonicum | Sjp_0080830 | U3 small nucleolar ribonucleoprotein protein IMP3, putative |
Schistosoma mansoni | Smp_102820 | ribosomal protein related |
Schmidtea mediterranea | mk4.000244.07 | Putative 40S ribosomal protein S4-like |
Trypanosoma brucei gambiense | Tbg972.11.15560 | U3 small nucleolar ribonucleoprotein protein IMP3, putative |
Trypanosoma brucei | Tb927.11.13930 | U3 small nucleolar ribonucleoprotein protein IMP3, putative |
Trypanosoma congolense | TcIL3000.11.14300 | U3 small nucleolar ribonucleoprotein protein IMP3, putative |
Trypanosoma cruzi | TcCLB.509161.20 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.504643.20 | hypothetical protein, conserved |
Toxoplasma gondii | TGME49_209430 | 40S ribosomal protein S4, putative |
Theileria parva | TP03_0429 | 40S ribosomal protein S4, putative |
Trichomonas vaginalis | TVAG_221740 | 30S 40S ribosomal protein, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.01.5500 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.01.5500 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.01.5500 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.01.5500 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_C48B6.2 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_C48B6.2 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_C48B6.2 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_C48B6.2 | Caenorhabditis elegans | slow growth | wormbase |
CELE_C48B6.2 | Caenorhabditis elegans | sterile | wormbase |
YHR148W | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_209430 | Toxoplasma gondii | Probably essential | sidik |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.