pI: 4.7741 |
Length (AA): 191 |
MW (Da): 22109 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
5 | 190 | 3cue (D) | 8 | 193 | 40.00 | 0 | 1 | 1.49312 | -0.56 |
19 | 183 | 6aq3 (A) | 16 | 181 | 48.00 | 0 | 1 | 1.51327 | -1.07 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Rahman HM-1 IMSS Trophozoite. | Hon CC |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Trophozoite. | Hon CC |
Hon CC | Transcriptomics of virulent and avirulent strains |
Ortholog group members (OG5_128128)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G54750 | transport protein particle (TRAPP) component |
Babesia bovis | BBOV_IV004220 | Bet3 transport protein, putative |
Brugia malayi | Bm1_41185 | trappc3-prov protein |
Candida albicans | CaO19.5817 | Low MW subunit of Transport Protein Particle (TRAPP) |
Candida albicans | CaO19.13239 | Low MW subunit of Transport Protein Particle (TRAPP) |
Caenorhabditis elegans | CELE_ZK1098.5 | Protein ZK1098.5 |
Cryptosporidium hominis | Chro.70212 | similar to transport protein particle component Bet3p-like protein; protein id: At5g54750.1, supported by cDNA: 122866. |
Cryptosporidium parvum | cgd7_1820 | BET3 vesicular transport protein |
Dictyostelium discoideum | DDB_G0277135 | trafficking protein particle complex subunit 3 |
Drosophila melanogaster | Dmel_CG3911 | BET3 ortholog (S. cerevisiae) |
Echinococcus granulosus | EgrG_000929800 | Trafficking protein particle complex subunit 3 |
Entamoeba histolytica | EHI_025820 | transport protein particle, Bet3 subunit, putative |
Echinococcus multilocularis | EmuJ_000929800 | Trafficking protein particle complex subunit 3 |
Giardia lamblia | GL50803_8003 | Bet3-like protein |
Homo sapiens | ENSG00000054116 | trafficking protein particle complex 3 |
Leishmania braziliensis | LbrM.16.1460 | trafficking protein particle complex subunit- like protein |
Leishmania donovani | LdBPK_161480.1 | trafficking protein particle complex subunit- like protein |
Leishmania infantum | LinJ.16.1480 | trafficking protein particle complex subunit- like protein |
Leishmania major | LmjF.16.1400 | trafficking protein particle complex subunit- like protein |
Leishmania mexicana | LmxM.16.1400 | trafficking protein particle complex subunit- like protein |
Loa Loa (eye worm) | LOAG_01022 | trappc3-prov protein |
Mus musculus | ENSMUSG00000028847 | trafficking protein particle complex 3 |
Neospora caninum | NCLIV_009310 | trafficking protein particle complex subunit 3, putative |
Oryza sativa | 4344075 | Os07g0642300 |
Oryza sativa | 4333064 | Os03g0402000 |
Plasmodium berghei | PBANKA_0720600 | trafficking protein particle complex subunit 3, putative |
Plasmodium falciparum | PF3D7_0418500 | trafficking protein particle complex subunit 3, putative |
Plasmodium knowlesi | PKNH_0510900 | trafficking protein particle complex subunit 3, putative |
Plasmodium vivax | PVX_090015 | trafficking protein particle complex subunit 3, putative |
Plasmodium yoelii | PY02417 | transport protein particle component Bet3p-like protein |
Saccharomyces cerevisiae | YKR068C | TRAPP complex core subunit BET3 |
Schistosoma mansoni | Smp_149360 | hypothetical protein |
Schmidtea mediterranea | mk4.005209.03 | Trafficking protein particle complex subunit 3 |
Schmidtea mediterranea | mk4.006518.00 | Trafficking protein particle complex subunit 3 |
Trypanosoma brucei gambiense | Tbg972.8.4830 | trafficking protein particle complex subunit 3, putative,TRAPP, putative,transport protein particle (TRAPP) component, Bet3, put |
Trypanosoma brucei | Tb927.8.5030 | transport protein particle (TRAPP) component, Bet3, putative |
Trypanosoma congolense | TcIL3000_8_4780 | transport protein particle (TRAPP) component, Bet3, putative |
Trypanosoma cruzi | TcCLB.508961.30 | trafficking protein particle complex subunit 3, putative |
Trypanosoma cruzi | TcCLB.447705.19 | trafficking protein particle complex subunit 3, putative |
Trypanosoma cruzi | TcCLB.508839.30 | trafficking protein particle complex subunit 3, putative |
Toxoplasma gondii | TGME49_299200 | Bet3 transport protein, putative |
Theileria parva | TP01_0332 | bet3 transport protein, putative |
Trichomonas vaginalis | TVAG_148000 | trafficking protein particle complex subunit, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.8.5030 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.8.5030 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.8.5030 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.8.5030 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_ZK1098.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
YKR068C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0720600 | Plasmodium berghei | Slow | plasmo |
TGME49_299200 | Toxoplasma gondii | Probably essential | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.