Detailed view for EHI_063010

Basic information

TDR Targets ID: 800416
Entamoeba histolytica, serine/threonine protein kinase, putative
Source Database / ID:  AmoebaDB  

pI: 8.2534 | Length (AA): 1071 | MW (Da): 122408 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 275 2xik (A) 19 283 40.00 0 1 0.767669 -0.81
2 262 2rku (A) 53 311 26.00 0 1 0.651197 -0.97
2 415 5t6a (A) 51 482 23.00 0 1 0.507155 0.03
7 257 4bf2 (A) 685 939 41.00 0 1 0.67786 -0.73
7 262 4ks7 (A) 412 664 36.00 0 1 0.717529 -0.68
36 1070 1u6g (C) 37 1155 10.00 0 1 0.867987 0.89

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile Trophozoite, Rahman HM-1 IMSS Trophozoite. Hon CC
Show/Hide expression data references
  • Hon CC Transcriptomics of virulent and avirulent strains

Orthologs

Ortholog group members (OG5_131527)

Species Accession Gene Product
Arabidopsis thaliana AT3G13530   MAP3K epsilon protein kinase 1
Arabidopsis thaliana AT3G07980   mitogen-activated protein kinase kinase kinase 6
Candida albicans CaO19.3545   potential protein kinase similar to A.nidulans gene (sepH) required for septation in cytokinesis
Candida albicans CaO19.11029   MAPKKK essential for late nuclear division
Dictyostelium discoideum DDB_G0276465   armadillo repeat-containing protein
Entamoeba histolytica EHI_063010   serine/threonine protein kinase, putative
Entamoeba histolytica EHI_009590   serine/threonine protein kinase, putative
Giardia lamblia GL50803_16834   Kinase, STE Dicty2
Oryza sativa 4337283   Os04g0660500
Schmidtea mediterranea mk4.003900.04   Casein kinase II subunit beta
Schmidtea mediterranea mk4.020131.00  
Schmidtea mediterranea mk4.000517.00   Mitogen-activated protein kinase kinase kinase 19
Trichomonas vaginalis TVAG_091160   STE family protein kinase
Trichomonas vaginalis TVAG_038280   STE family protein kinase
Trichomonas vaginalis TVAG_441070   STE family protein kinase

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Serine/threonine-protein kinase pim-3 326 aa 25.1% 271 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 28.5% 288 aa Compounds References
Bos taurus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 26.3% 293 aa Compounds References
Rattus norvegicus Jak1 protein 210 aa 25.6% 199 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 28.2% 287 aa Compounds References
Rattus norvegicus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 27.0% 293 aa Compounds References
Oryctolagus cuniculus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 25.9% 293 aa Compounds References
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 28.9% 197 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 25.9% 282 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0093 0.8828 0
0.0032 0.5 0.5
0.0081 1 0.5
0.0088 0.4477 0.5
0.0056 1 0.5
0.0064 0.3377 0.8757
0.0063 0.7244 0
0.0022 0.5 0.5
0.0059 1 1
0.0007 0.5 0.5
0.0012 0.5 0.5
0.0016 0.5 0.5
0.0033 1 1
0.0012 0.5 0.5
0.0012 0.5 0.5
0.0003 0.5 0.5
0.0039 0.5 0.5
0.0032 0.5 0.5
0.0037 1 0.5
0.0069 0.3067 0.5
0.0059 1 1
0.0018 0.5 0.5
0.0042 0.5 0.5
0.0007 0.5 0.5
0.0063 1 1
0.0033 0.5 0.5
0.0081 0.5 0.5
0.0091 1 0.5
0.0004 0.5 0.5
0.0062 0.6935 0
0.0059 1 1
0.0098 0.3242 0.3167
0.0039 0.9485 0.5
0.0007 0.5 0.5
0.0023 0.5 0.5
0.0029 0.5 0.5
0.0092 1 0.5
0.0011 1 0.5
0.0008 0.5 0.5
0.0026 0.5 0.5
0.0039 0.5 0.5
0.0036 0.5 0.5
0.0061 0.6883 0.6247
0.0067 0.5 0.5
0.0016 0.5 0.5
0.0027 1 0.5
0.0066 0.3101 0

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier EHI_063010 (Entamoeba histolytica), serine/threonine protein kinase, putative
Title for this comment
Comment